kae1 protein (Archaeoglobus fulgidus) - STRING interaction network

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kae1

O-sialoglycoprotein endopeptidase (gcp); Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Kae1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. (323 aa)

Predicted Functional Partners:

AF_0665

0.985

AF_0781

0.922

rps24e

0.920

AF_1117

0.918

flpA

0.918

pheS

0.907

AF_0519

0.888

AF_1115

0.885

spt4

0.881

rps27ae

0.872

Your Current Organism:

Archaeoglobus fulgidus

NCBI taxonomy Id: 224325
Other names: A. fulgidus DSM 4304, Archaeoglobus fulgidus DSM 4304, Archaeoglobus fulgidus VC-16, Archaeoglobus fulgidus str. DSM 4304, Archaeoglobus fulgidus strain DSM 4304

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AF_0519	AF_0665	AF_0519	AF_0665	Predicted coding region AF_0519; Hypothetical protein; identified by GeneMark; putative.	O-sialoglycoprotein endopeptidase, putative; Could be involved in the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine; Belongs to the protein kinase superfamily. Tyr protein kinase family. BUD32 subfamily.	0.884
AF_0519	kae1	AF_0519	AF_1112	Predicted coding region AF_0519; Hypothetical protein; identified by GeneMark; putative.	O-sialoglycoprotein endopeptidase (gcp); Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Kae1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity.	0.888
AF_0665	AF_0519	AF_0665	AF_0519	O-sialoglycoprotein endopeptidase, putative; Could be involved in the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine; Belongs to the protein kinase superfamily. Tyr protein kinase family. BUD32 subfamily.	Predicted coding region AF_0519; Hypothetical protein; identified by GeneMark; putative.	0.884
AF_0665	AF_0781	AF_0665	AF_0781	O-sialoglycoprotein endopeptidase, putative; Could be involved in the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine; Belongs to the protein kinase superfamily. Tyr protein kinase family. BUD32 subfamily.	Conserved hypothetical protein; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.	0.600
AF_0665	AF_1115	AF_0665	AF_1115	O-sialoglycoprotein endopeptidase, putative; Could be involved in the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine; Belongs to the protein kinase superfamily. Tyr protein kinase family. BUD32 subfamily.	Conserved hypothetical protein; Catalyzes the GTP-dependent phosphorylation of the 3'- hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).	0.727
AF_0665	AF_1117	AF_0665	AF_1117	O-sialoglycoprotein endopeptidase, putative; Could be involved in the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine; Belongs to the protein kinase superfamily. Tyr protein kinase family. BUD32 subfamily.	DNA-directed RNA polymerase, subunit E' (rpoE1); Similar to SP:Q57840 PID:1591102 GB:L77117 SP:Q57840 PID:1591102 percent identity: 48.35; identified by sequence similarity; putative.	0.791
AF_0665	flpA	AF_0665	AF_2087	O-sialoglycoprotein endopeptidase, putative; Could be involved in the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine; Belongs to the protein kinase superfamily. Tyr protein kinase family. BUD32 subfamily.	Fibrillarin (fib); Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA; Belongs to the methyltransferase superfamily. Fibrillarin family.	0.497
AF_0665	kae1	AF_0665	AF_1112	O-sialoglycoprotein endopeptidase, putative; Could be involved in the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine; Belongs to the protein kinase superfamily. Tyr protein kinase family. BUD32 subfamily.	O-sialoglycoprotein endopeptidase (gcp); Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Kae1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity.	0.985
AF_0665	pheS	AF_0665	AF_1955	O-sialoglycoprotein endopeptidase, putative; Could be involved in the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine; Belongs to the protein kinase superfamily. Tyr protein kinase family. BUD32 subfamily.	phenylalanyl-tRNA synthetase, subunit alpha (pheS); Similar to GB:L77117 SP:Q57911 PID:1592293 percent identity: 44.39; identified by sequence similarity; putative; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.	0.589
AF_0665	rps24e	AF_0665	AF_1114	O-sialoglycoprotein endopeptidase, putative; Could be involved in the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine; Belongs to the protein kinase superfamily. Tyr protein kinase family. BUD32 subfamily.	SSU ribosomal protein S24E (rps24E); Similar to GB:L77117 SP:P54032 PID:1591099 percent identity: 40.20; identified by sequence similarity; putative; Belongs to the eukaryotic ribosomal protein eS24 family.	0.806
AF_0665	rps27ae	AF_0665	AF_1113	O-sialoglycoprotein endopeptidase, putative; Could be involved in the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine; Belongs to the protein kinase superfamily. Tyr protein kinase family. BUD32 subfamily.	SSU ribosomal protein S27AE (rps27AE); Similar to GB:L77117 SP:P54031 PID:1591098 percent identity: 60.00; identified by sequence similarity; putative; Belongs to the eukaryotic ribosomal protein eS31 family.	0.727
AF_0665	spt4	AF_0665	AF_1116	O-sialoglycoprotein endopeptidase, putative; Could be involved in the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine; Belongs to the protein kinase superfamily. Tyr protein kinase family. BUD32 subfamily.	DNA-directed RNA polymerase, subunit E'' (rpoE2); Stimulates transcription elongation; Belongs to the archaeal Spt4 family.	0.760
AF_0781	AF_0665	AF_0781	AF_0665	Conserved hypothetical protein; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.	O-sialoglycoprotein endopeptidase, putative; Could be involved in the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine; Belongs to the protein kinase superfamily. Tyr protein kinase family. BUD32 subfamily.	0.600
AF_0781	kae1	AF_0781	AF_1112	Conserved hypothetical protein; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.	O-sialoglycoprotein endopeptidase (gcp); Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Kae1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity.	0.922
AF_1115	AF_0665	AF_1115	AF_0665	Conserved hypothetical protein; Catalyzes the GTP-dependent phosphorylation of the 3'- hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).	O-sialoglycoprotein endopeptidase, putative; Could be involved in the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine; Belongs to the protein kinase superfamily. Tyr protein kinase family. BUD32 subfamily.	0.727
AF_1115	AF_1117	AF_1115	AF_1117	Conserved hypothetical protein; Catalyzes the GTP-dependent phosphorylation of the 3'- hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).	DNA-directed RNA polymerase, subunit E' (rpoE1); Similar to SP:Q57840 PID:1591102 GB:L77117 SP:Q57840 PID:1591102 percent identity: 48.35; identified by sequence similarity; putative.	0.982
AF_1115	kae1	AF_1115	AF_1112	Conserved hypothetical protein; Catalyzes the GTP-dependent phosphorylation of the 3'- hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).	O-sialoglycoprotein endopeptidase (gcp); Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Kae1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity.	0.885
AF_1115	rps24e	AF_1115	AF_1114	Conserved hypothetical protein; Catalyzes the GTP-dependent phosphorylation of the 3'- hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).	SSU ribosomal protein S24E (rps24E); Similar to GB:L77117 SP:P54032 PID:1591099 percent identity: 40.20; identified by sequence similarity; putative; Belongs to the eukaryotic ribosomal protein eS24 family.	0.990
AF_1115	rps27ae	AF_1115	AF_1113	Conserved hypothetical protein; Catalyzes the GTP-dependent phosphorylation of the 3'- hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).	SSU ribosomal protein S27AE (rps27AE); Similar to GB:L77117 SP:P54031 PID:1591098 percent identity: 60.00; identified by sequence similarity; putative; Belongs to the eukaryotic ribosomal protein eS31 family.	0.942
AF_1115	spt4	AF_1115	AF_1116	Conserved hypothetical protein; Catalyzes the GTP-dependent phosphorylation of the 3'- hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).	DNA-directed RNA polymerase, subunit E'' (rpoE2); Stimulates transcription elongation; Belongs to the archaeal Spt4 family.	0.945

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