Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
AF_11973-ketoacyl-CoA thiolase (fadA-2); Similar to GB:U08465 SP:P45359 PID:475715 percent identity: 57.95; identified by sequence similarity; putative. (424 aa)    
Predicted Functional Partners:
AF_1190
3-hydroxyacyl-CoA dehydrogenase (hbd-7); Similar to PID:1055222 SP:P52041 percent identity: 46.45; identified by sequence similarity; putative.
 
 0.988
AF_2415
Acyl carrier protein synthase (acaA-2); Similar to PID:1197357 percent identity: 58.72; identified by sequence similarity; putative; Belongs to the thiolase-like superfamily. UPF0219 family.
  
 0.975
AF_1340
Citrate synthase (citZ); Similar to GB:U05257 SP:P39120 PID:487433 PID:2293267 GB:AL009126 percent identity: 50.27; identified by sequence similarity; putative.
  
 0.957
leuA
2-isopropylmalate synthase (leuA-2); Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate).
  
 
 0.933
AF_0197
acetyl-CoA synthetase (acs-1); Similar to SP:P27550 PID:396404 PID:148105 GB:U00096 PID:1790505 percent identity: 27.14; identified by sequence similarity; putative.
  
 
 0.926
hmgA
3-hydroxy-3-methylglutaryl-coenzyme A reductase (mvaA); Converts HMG-CoA to mevalonate.
 
  
 0.917
AF_1025
3-hydroxyacyl-CoA dehydrogenase (hbd-4); Similar to PID:1055222 SP:P52041 percent identity: 45.58; identified by sequence similarity; putative.
 
 0.903
AF_1122
3-hydroxyacyl-CoA dehydrogenase (hbd-5); Similar to PID:1055222 SP:P52041 percent identity: 45.20; identified by sequence similarity; putative.
  
 0.887
AF_0285
3-hydroxyacyl-CoA dehydrogenase (hbd-2); Similar to PID:1055222 SP:P52041 percent identity: 55.79; identified by sequence similarity; putative; Belongs to the enoyl-CoA hydratase/isomerase family.
  
 0.882
AF_2273
3-hydroxyacyl-CoA dehydrogenase (hbd-10); Similar to PID:1055222 SP:P52041 percent identity: 47.35; identified by sequence similarity; putative; Belongs to the enoyl-CoA hydratase/isomerase family.
  
 0.882
Your Current Organism:
Archaeoglobus fulgidus
NCBI taxonomy Id: 224325
Other names: A. fulgidus DSM 4304, Archaeoglobus fulgidus DSM 4304, Archaeoglobus fulgidus VC-16, Archaeoglobus fulgidus str. DSM 4304, Archaeoglobus fulgidus strain DSM 4304
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