close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
trpB2Tryptophan synthase, subunit beta (trpB-1); The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (435 aa)    
Predicted Functional Partners:
trpA
Tryptophan synthase, subunit alpha (trpA); The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.
  
 0.999
trpCD
Anthranilate synthase component II (trpD); Bifunctional enzyme that catalyzes the second and fourth steps of tryptophan biosynthetic pathway. The second step is catalyzed by the anthranilate phosphoribosyltransferase, coded by the TrpD domain and the fourth step is catalyzed by indole-3-glycerol phosphate synthase, coded by the TrpC domain (By similarity).
 
  
 0.949
trpB1
Tryptophan synthase, subunit beta (trpB-2); The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.
  
 
0.948
glyA
Serine hydroxymethyltransferase (glyA); Catalyzes the reversible interconversion of serine and glycine with tetrahydromethanopterin (H4MPT) serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro- aldol mechanism; Belongs to the SHMT family.
    
 0.911
AF_2044
CDP-diacylglycerol--serine O-phosphatidyltransferase (pssA); Similar to GB:L77117 SP:Q58609 PID:1591841 percent identity: 36.65; identified by sequence similarity; putative.
     
  0.900
AF_2138
Phosphoserine phosphatase (serB); Similar to GB:L77117 PID:1592204 percent identity: 50.71; identified by sequence similarity; putative; Belongs to the HAD-like hydrolase superfamily. SerB family.
    
  0.900
AF_1239
Ferredoxin (fdx-7); Similar to percent identity: 28.99; identified by sequence similarity; putative.
       0.587
hemC
Porphobilinogen deaminase (hemC); Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
       0.557
AF_1244
Predicted coding region AF_1244; Hypothetical protein; identified by GeneMark; putative.
       0.556
AF_1243
uroporphyrin-III C-methyltransferase (cysG-2); Similar to GB:L77117 PID:1591629 percent identity: 52.52; identified by sequence similarity; putative.
       0.554
Your Current Organism:
Archaeoglobus fulgidus
NCBI taxonomy Id: 224325
Other names: A. fulgidus DSM 4304, Archaeoglobus fulgidus DSM 4304, Archaeoglobus fulgidus VC-16, Archaeoglobus fulgidus str. DSM 4304, Archaeoglobus fulgidus strain DSM 4304
Server load: low (32%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.