STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hemCPorphobilinogen deaminase (hemC); Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. (289 aa)    
Predicted Functional Partners:
hemB
Porphobilinogen synthase (hemB); Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity).
 
 0.998
AF_0116
Uroporphyrinogen III synthase (hemD); Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
 
 0.997
hemA
glutamyl-tRNA reductase (hemA); Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
  
 0.997
AF_1243
uroporphyrin-III C-methyltransferase (cysG-2); Similar to GB:L77117 PID:1591629 percent identity: 52.52; identified by sequence similarity; putative.
  
 0.994
hemL
Glutamate-1-semialdehyde aminotransferase (hemL); Similar to GB:L77117 SP:Q58020 PID:1591312 percent identity: 54.31; identified by sequence similarity; putative; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
  
 0.991
AF_0422
uroporphyrin-III C-methyltransferase (cysG-1); Similar to GB:L77117 PID:1591629 percent identity: 41.74; identified by sequence similarity; putative.
  
 0.973
cbiHC
Cobalamin biosynthesis precorrin-3 methylase (cbiH); Bifunctional enzyme with a methyltransferase domain that catalyzes the ring contraction and methylation of C-17 in cobalt-factor III to form cobalt-factor IV, and an isomerase domain that catalyzes the conversion of cobalt-precorrin-8 to cobyrinate; In the C-terminal section; belongs to the CobH family.
     
 0.932
AF_0726
Cobalamin biosynthesis precorrin-3 methylase (cbiF); Similar to GB:L77117 PID:1500473 percent identity: 49.16; identified by sequence similarity; putative.
    
 0.882
AF_1245
Na+/H+ antiporter (napA-2); Similar to SP:P26235 PID:148316 percent identity: 28.41; identified by sequence similarity; putative.
 
     0.782
AF_0007
Predicted coding region AF_0007; Hypothetical protein; identified by GeneMark; putative.
  
 
 0.757
Your Current Organism:
Archaeoglobus fulgidus
NCBI taxonomy Id: 224325
Other names: A. fulgidus DSM 4304, Archaeoglobus fulgidus DSM 4304, Archaeoglobus fulgidus VC-16, Archaeoglobus fulgidus str. DSM 4304, Archaeoglobus fulgidus strain DSM 4304
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