STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
fae-hpsD-arabino 3-hexulose 6-phosphate formaldehyde lyase (hps-2); Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10- methylenetetrahydromethanopterin; In the C-terminal section; belongs to the HPS/KGPDC family. HPS subfamily. (394 aa)    
Predicted Functional Partners:
AF_1796
Conserved hypothetical protein; Similar to SP:P42404 PID:710636 PID:1438846 PID:1805417 GB:AL009126 percent identity: 36.61; identified by sequence similarity; putative; Belongs to the SIS family. PHI subfamily.
 
 0.997
ftr
Formylmethanofuran:tetrahydromethanopterin formyltransferase (ftr-2); Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT).
  
  
 0.978
AF_2073
Formylmethanofuran:tetrahydromethanopterin formyltransferase (ftr-1); Similar to GB:X70784 PID:452327 SP:Q49168 percent identity: 45.97; identified by sequence similarity; putative; Belongs to the FTR family.
  
  
 0.973
mtd
N5,N10-methylenetetrahydromethanopterin dehydrogenase (mtd); Catalyzes the oxidation of methylene-H(4)MPT to methenyl- H(4)MPT(+); Belongs to the MTD family.
     
 0.970
rpiA
Ribose 5-phosphate isomerase (rpi); Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
    
 0.960
AF_0861
D-arabino 3-hexulose 6-phosphate formaldehyde lyase (hps-1); Similar to GB:L77117 SP:Q58842 PID:1592092 percent identity: 30.59; identified by sequence similarity; putative.
 
  
0.954
glyA
Serine hydroxymethyltransferase (glyA); Catalyzes the reversible interconversion of serine and glycine with tetrahydromethanopterin (H4MPT) serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro- aldol mechanism; Belongs to the SHMT family.
 
  
 0.928
mer
N5,N10-methylenetetrahydromethanopterin reductase (mer-1); Catalyzes the oxidation of methyl-H(4)MPT to methylene- H(4)MPT; Belongs to the mer family.
  
  
  0.914
cdhE
acetyl-CoA decarbonylase/synthase, subunit gamma (cdhE); Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2).
     
  0.900
cdhD
acetyl-CoA decarbonylase/synthase, subunit delta (cdhD); Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). Probably maintains the overall quaternary structure of the ACDS complex. Belongs to the CdhD family.
     
  0.900
Your Current Organism:
Archaeoglobus fulgidus
NCBI taxonomy Id: 224325
Other names: A. fulgidus DSM 4304, Archaeoglobus fulgidus DSM 4304, Archaeoglobus fulgidus VC-16, Archaeoglobus fulgidus str. DSM 4304, Archaeoglobus fulgidus strain DSM 4304
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