Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
hypAHydrogenase expression/formation protein (hypA); Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. (110 aa)    
Predicted Functional Partners:
AF_1368
Hydrogenase expression/formation protein (hypB); Similar to GB:L77117 SP:Q57884 PID:1591146 percent identity: 54.37; identified by sequence similarity; putative.
 
 
 0.996
AF_1370
Hydrogenase expression/formation protein (hypD); Similar to GB:L77117 SP:Q58400 PID:1591656 percent identity: 46.02; identified by sequence similarity; putative.
 
  
 0.954
AF_1366
Hydrogenase expression/formation regulatory protein (hypF); Similar to GB:L77117 PID:1591430 percent identity: 45.08; identified by sequence similarity; putative.
 
   
 0.948
AF_1365
Hydrogenase expression/formation protein (hypE); Similar to GB:L77117 SP:Q58089 PID:1591391 percent identity: 51.52; identified by sequence similarity; putative.
 
  
 0.947
AF_1372
Methylviologen-reducing hydrogenase, subunit alpha (vhuA); Similar to GB:L77117 PID:1591820 percent identity: 39.40; identified by sequence similarity; putative.
  
 
 0.931
AF_1380
F420-nonreducing hydrogenase (vhtA); Similar to PID:602583 percent identity: 34.82; identified by sequence similarity; putative.
 
 
 0.891
AF_1369
Hydrogenase expression/formation protein (hypC); Similar to GB:L77117 SP:Q57653 PID:1498975 percent identity: 40.54; identified by sequence similarity; putative.
 
  
 0.863
AF_2269
Nucleotide-binding protein; Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP; Belongs to the Mrp/NBP35 ATP-binding proteins family.
   
   0.796
AF_2382
Nucleotide-binding protein; Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP; Belongs to the Mrp/NBP35 ATP-binding proteins family.
   
   0.796
trpCD
Anthranilate synthase component II (trpD); Bifunctional enzyme that catalyzes the second and fourth steps of tryptophan biosynthetic pathway. The second step is catalyzed by the anthranilate phosphoribosyltransferase, coded by the TrpD domain and the fourth step is catalyzed by indole-3-glycerol phosphate synthase, coded by the TrpC domain (By similarity).
      
 0.718
Your Current Organism:
Archaeoglobus fulgidus
NCBI taxonomy Id: 224325
Other names: A. fulgidus DSM 4304, Archaeoglobus fulgidus DSM 4304, Archaeoglobus fulgidus VC-16, Archaeoglobus fulgidus str. DSM 4304, Archaeoglobus fulgidus strain DSM 4304
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