Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
AF_1380F420-nonreducing hydrogenase (vhtA); Similar to PID:602583 percent identity: 34.82; identified by sequence similarity; putative. (569 aa)    
Predicted Functional Partners:
AF_1381
F420-nonreducing hydrogenase (vhtG); Similar to PID:602582 percent identity: 46.11; identified by sequence similarity; putative.
 
 
 0.998
AF_0662
Heterodisulfide reductase, subunit A/methylviologen reducing hydrogenase, subunit delta; Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).
  
 
 0.980
AF_1378
F420-nonreducing hydrogenase (vhtD-2); Similar to PID:1016350 percent identity: 33.11; identified by sequence similarity; putative.
 
  
 0.967
AF_1373
Methylviologen-reducing hydrogenase, subunit gamma (vhuG); Similar to GB:X61204 PID:44798 PID:1747407 percent identity: 38.60; identified by sequence similarity; putative.
 
 
 0.926
AF_1379
Quinone-reactive Ni/Fe-hydrogenase B-type cytochrome subunit (hydC); Similar to SP:P31875 PID:48518 percent identity: 29.03; identified by sequence similarity; putative.
  
  
 0.911
AF_1374
Methylviologen-reducing hydrogenase, subunit delta (vhuD); Similar to GB:J04540 PID:149731 GB:AE000666 percent identity: 41.67; identified by sequence similarity; putative.
  
 
 0.901
AF_1370
Hydrogenase expression/formation protein (hypD); Similar to GB:L77117 SP:Q58400 PID:1591656 percent identity: 46.02; identified by sequence similarity; putative.
 
 
 0.897
hypA
Hydrogenase expression/formation protein (hypA); Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.
 
 
 0.891
AF_1833
F420H2:quinone oxidoreductase, 39 kDa subunit, putative; Similar to GB:X61202 PID:44708 percent identity: 33.60; identified by sequence similarity; putative.
  
 
 0.866
AF_1375
Heterodisulfide reductase, subunit B (hdrB); Similar to GB:L77117 PID:1591548 percent identity: 36.00; identified by sequence similarity; putative.
  
 
 0.852
Your Current Organism:
Archaeoglobus fulgidus
NCBI taxonomy Id: 224325
Other names: A. fulgidus DSM 4304, Archaeoglobus fulgidus DSM 4304, Archaeoglobus fulgidus VC-16, Archaeoglobus fulgidus str. DSM 4304, Archaeoglobus fulgidus strain DSM 4304
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