Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
AF_1400Conserved hypothetical protein; Similar to GB:L77117 PID:1500511 percent identity: 32.53; identified by sequence similarity; putative. (188 aa)    
Predicted Functional Partners:
cobQ
Cobyric acid synthase (cbiP); Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity); Belongs to the CobB/CobQ family. CobQ subfamily.
 
  
 0.972
cobD
Cobalamin biosynthesis protein (cbiB); Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
 
  
  0.963
cbiHC
Cobalamin biosynthesis precorrin-3 methylase (cbiH); Bifunctional enzyme with a methyltransferase domain that catalyzes the ring contraction and methylation of C-17 in cobalt-factor III to form cobalt-factor IV, and an isomerase domain that catalyzes the conversion of cobalt-precorrin-8 to cobyrinate; In the C-terminal section; belongs to the CobH family.
     
 0.961
AF_1290
Conserved hypothetical protein; Similar to SP:P45515 PID:493088 percent identity: 31.54; identified by sequence similarity; putative.
  
 
  0.940
AF_1401
Iron (III) ABC transporter, ATP-binding protein (hemV-3); Similar to GB:L77117 PID:1591556 percent identity: 35.19; identified by sequence similarity; putative.
 
   
 0.884
AF_1402
Iron (III) ABC transporter, permease protein (hemU-2); Similar to GB:L42023 PID:1007599 PID:1221614 PID:1205706 SP:Q57130 percent identity: 35.22; identified by sequence similarity; putative.
  
  
 0.822
AF_1404
Transcriptional regulatory protein, AsnC family; Similar to GB:L10328 SP:P03809 GB:K00826 PID:290592 PID:455179 percent identity: 45.10; identified by sequence similarity; putative.
 
     0.765
AF_1403
Conserved hypothetical protein; Similar to GB:L77117 PID:1592100 percent identity: 58.99; identified by sequence similarity; putative.
       0.723
AF_2321
Conserved hypothetical protein; Similar to GB:L77117 PID:1591756 percent identity: 40.12; identified by sequence similarity; putative.
 
     0.682
AF_0276
Conserved hypothetical protein; Similar to GB:L77117 PID:1500495 percent identity: 40.12; identified by sequence similarity; putative; Belongs to the UPF0284 family.
 
     0.664
Your Current Organism:
Archaeoglobus fulgidus
NCBI taxonomy Id: 224325
Other names: A. fulgidus DSM 4304, Archaeoglobus fulgidus DSM 4304, Archaeoglobus fulgidus VC-16, Archaeoglobus fulgidus str. DSM 4304, Archaeoglobus fulgidus strain DSM 4304
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