Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
AF_1449Pyruvate formate-lyase 2 (pflD); Similar to SP:P32674 GB:U00006 PID:396298 GB:U00096 PID:1790388 percent identity: 37.81; identified by sequence similarity; putative. (776 aa)    
Predicted Functional Partners:
AF_1450
Pyruvate formate-lyase 2 activating enzyme (pflC); Similar to SP:P32675 PID:396299 GB:U00096 PID:1790389 percent identity: 38.77; identified by sequence similarity; putative.
  
 0.996
AF_0117
Pyruvate formate-lyase activating enzyme (act-1); Similar to GB:L77117 PID:1591858 percent identity: 25.47; identified by sequence similarity; putative.
  
  
 0.759
AF_1330
Pyruvate formate-lyase activating enzyme (act-3); Similar to GB:L77117 SP:Q58218 PID:1499631 percent identity: 45.81; identified by sequence similarity; putative.
  
  
 0.759
AF_2278
Pyruvate formate-lyase activating enzyme (act-4); Similar to GB:L77117 SP:Q58218 PID:1499631 percent identity: 42.46; identified by sequence similarity; putative.
  
  
 0.759
AF_1448
Transcriptional regulatory protein, AsnC family; Similar to GB:L77117 SP:Q58133 PID:1591440 percent identity: 30.58; identified by sequence similarity; putative.
       0.661
mdh
L-malate dehydrogenase, NAD+-dependent (mdhA); Catalyzes the reversible oxidation of malate to oxaloacetate. Can also oxidize tartrate.
  
  
 0.631
thsB
Thermosome, subunit beta (thsB); Molecular chaperone; binds unfolded polypeptides in vitro, and has a weak ATPase activity; Belongs to the TCP-1 chaperonin family.
     
 0.581
trpCD
Anthranilate synthase component II (trpD); Bifunctional enzyme that catalyzes the second and fourth steps of tryptophan biosynthetic pathway. The second step is catalyzed by the anthranilate phosphoribosyltransferase, coded by the TrpD domain and the fourth step is catalyzed by indole-3-glycerol phosphate synthase, coded by the TrpC domain (By similarity).
  
  
 0.535
AF_1340
Citrate synthase (citZ); Similar to GB:U05257 SP:P39120 PID:487433 PID:2293267 GB:AL009126 percent identity: 50.27; identified by sequence similarity; putative.
     
 0.519
AF_0991
glutaryl-CoA dehydrogenase (gcdH); Similar to GB:U69141 SP:Q92947 PID:1549327 PID:1905909 PID:2316112 percent identity: 48.68; identified by sequence similarity; putative.
      
 0.518
Your Current Organism:
Archaeoglobus fulgidus
NCBI taxonomy Id: 224325
Other names: A. fulgidus DSM 4304, Archaeoglobus fulgidus DSM 4304, Archaeoglobus fulgidus VC-16, Archaeoglobus fulgidus str. DSM 4304, Archaeoglobus fulgidus strain DSM 4304
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