Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
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Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
AF_1463Fumarate reductase, flavoprotein subunit (fdrA) {Mycobacterium tuberculosis); Similar to SP:Q10760 PID:1403490 percent identity: 26.96; identified by sequence similarity; putative. (575 aa)    
Predicted Functional Partners:
AF_0682
Succinate dehydrogenase, iron-sulfur subunit B (sdhB); Similar to GB:X70908 PID:396212 percent identity: 51.27; identified by sequence similarity; putative.
 
 0.989
AF_0683
Succinate dehydrogenase, subunit C (sdhC); Similar to GP:1524299 percent identity: 36.56; identified by sequence similarity; putative.
  
 0.980
sdhD
Succinate dehydrogenase, subunit D (sdhD); Membrane-anchoring subunit of succinate dehydrogenase (SDH).
  
 
 0.942
AF_1461
Iron-sulfur cluster binding protein, putative; Similar to GP:1747410 percent identity: 50.98; identified by sequence similarity; putative.
 
  
 0.852
AF_1340
Citrate synthase (citZ); Similar to GB:U05257 SP:P39120 PID:487433 PID:2293267 GB:AL009126 percent identity: 50.27; identified by sequence similarity; putative.
  
 
 0.840
AF_1830
F420H2:quinone oxidoreductase, 45 kDa subunit (nuoD); Similar to PIR:S45666 percent identity: 80.00; identified by sequence similarity; putative.
  
 
 0.839
AF_1462
Predicted coding region AF_1462; Hypothetical protein; identified by GeneMark; putative.
       0.773
mdh
L-malate dehydrogenase, NAD+-dependent (mdhA); Catalyzes the reversible oxidation of malate to oxaloacetate. Can also oxidize tartrate.
  
 
 0.709
sucC1
succinyl-CoA synthetase, beta subunit (sucC-1); Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
  
 
 0.709
sucC2
succinyl-CoA synthetase, beta subunit (sucC-2); Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
  
 
 0.709
Your Current Organism:
Archaeoglobus fulgidus
NCBI taxonomy Id: 224325
Other names: A. fulgidus DSM 4304, Archaeoglobus fulgidus DSM 4304, Archaeoglobus fulgidus VC-16, Archaeoglobus fulgidus str. DSM 4304, Archaeoglobus fulgidus strain DSM 4304
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