Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
AF_1483Signal-transducing histidine kinase; Similar to PID:1652120 percent identity: 27.72; identified by sequence similarity; putative. (908 aa)    
Predicted Functional Partners:
AF_1037
Chemotaxis protein methyltransferase (cheR); Similar to PID:1177141 percent identity: 33.21; identified by sequence similarity; putative.
 
     0.915
AF_1484
Predicted coding region AF_1484; Hypothetical protein; identified by GeneMark; putative.
       0.773
AF_1473
Response regulator; Similar to PID:1086465 percent identity: 38.64; identified by sequence similarity; putative.
 
     0.698
AF_2419
Response regulator; Similar to PID:1086465 percent identity: 37.93; identified by sequence similarity; putative.
 
     0.633
AF_1898
Response regulator; Similar to PID:940149 percent identity: 48.70; identified by sequence similarity; putative.
 
     0.619
AF_0449
Response regulator; Similar to GB:M59781 SP:P24072 PID:142682 GB:AL009126 percent identity: 38.14; identified by sequence similarity; putative.
 
     0.599
AF_2249
Response regulator; Similar to PID:940149 percent identity: 44.83; identified by sequence similarity; putative.
 
     0.599
AF_1384
Response regulator; Similar to PID:940149 percent identity: 44.74; identified by sequence similarity; putative.
 
     0.589
AF_1256
Response regulator; Similar to PID:940149 percent identity: 42.45; identified by sequence similarity; putative.
 
     0.569
tgt
Queuine tRNA-ribosyltransferase (tgtB); Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to [...]
       0.549
Your Current Organism:
Archaeoglobus fulgidus
NCBI taxonomy Id: 224325
Other names: A. fulgidus DSM 4304, Archaeoglobus fulgidus DSM 4304, Archaeoglobus fulgidus VC-16, Archaeoglobus fulgidus str. DSM 4304, Archaeoglobus fulgidus strain DSM 4304
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