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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
tmcAConserved hypothetical protein; Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP). (765 aa)    
Predicted Functional Partners:
AF_2088
Conserved hypothetical protein; Similar to GB:L77117 SP:Q58105 PID:1591409 percent identity: 38.19; identified by sequence similarity; putative.
  
 
 0.994
AF_1805
Conserved hypothetical protein; Similar to GB:L77117 SP:Q57885 PID:1591147 percent identity: 48.52; identified by sequence similarity; putative.
   
 
 0.981
rtcA
Conserved hypothetical protein; Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing (By similarity).
   
 
 0.955
truB
Centromere/microtubule-binding protein (cbf5); Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 2 subfamily.
  
 
 0.949
nep1
Conserved hypothetical protein; Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA.
  
 
 0.948
rpl7ae
LSU ribosomal protein L7AE (rpl7AE); Multifunctional RNA-binding protein that recognizes the K- turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.
 
 
 0.932
AF_2226
Conserved hypothetical protein; Similar to GB:L77117 SP:Q57864 PID:1591124 percent identity: 47.67; identified by sequence similarity; putative.
  
 0.932
rps3ae
SSU ribosomal protein S3AE (rps3AE); Similar to GB:L77117 SP:P54059 PID:1499819 percent identity: 39.42; identified by sequence similarity; putative; Belongs to the eukaryotic ribosomal protein eS1 family.
  
   0.904
AF_0428
GTP-binding protein, GTP1/OBG-family; Similar to GB:L77117 PID:1592057 percent identity: 43.92; identified by sequence similarity; putative.
  
 
 0.895
rps15
SSU ribosomal protein S15P (rps15P); Similar to GB:L77117 SP:P54012 PID:1590839 percent identity: 62.00; identified by sequence similarity; putative.
  
 
 0.890
Your Current Organism:
Archaeoglobus fulgidus
NCBI taxonomy Id: 224325
Other names: A. fulgidus DSM 4304, Archaeoglobus fulgidus DSM 4304, Archaeoglobus fulgidus VC-16, Archaeoglobus fulgidus str. DSM 4304, Archaeoglobus fulgidus strain DSM 4304
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