Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
nreBPredicted coding region AF_1590; Involved in DNA damage repair. (391 aa)    
Predicted Functional Partners:
AF_1589
Conserved hypothetical protein; Similar to GB:L77117 SP:Q58096 PID:1591398 percent identity: 37.62; identified by sequence similarity; putative.
       0.803
AF_1588
Conserved hypothetical protein; Similar to PID:1001103 PID:1001125 percent identity: 25.75; identified by sequence similarity; putative.
 
     0.664
AF_1355
Predicted coding region AF_1355; Hypothetical protein; identified by GeneMark; putative.
 
     0.657
AF_0472
Predicted coding region AF_0472; Hypothetical protein; identified by GeneMark; putative.
 
     0.640
fen
DNA repair protein RAD2 (rad2); Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) [...]
  
   
 0.632
cdc6-1
Cell division control protein 6, putative; Involved in regulation of DNA replication.
  
     0.618
AF_0794
Predicted coding region AF_0794; Hypothetical protein; identified by GeneMark; putative.
 
     0.617
AF_1797
Phosphate regulatory protein, putative; Similar to PID:633996 percent identity: 30.67; identified by sequence similarity; putative.
 
     0.616
nac
Conserved hypothetical protein; Contacts the emerging nascent chain on the ribosome. Belongs to the NAC-alpha family.
  
     0.615
AF_1587
Ribulose bisphosphate carboxylase, large subunit (rbcL-1); May be involved in sulfur metabolism and oxidative stress response. Does not show RuBisCO activity (By similarity).
       0.615
Your Current Organism:
Archaeoglobus fulgidus
NCBI taxonomy Id: 224325
Other names: A. fulgidus DSM 4304, Archaeoglobus fulgidus DSM 4304, Archaeoglobus fulgidus VC-16, Archaeoglobus fulgidus str. DSM 4304, Archaeoglobus fulgidus strain DSM 4304
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