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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
trpB1Tryptophan synthase, subunit beta (trpB-2); The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (397 aa)    
Predicted Functional Partners:
trpA
Tryptophan synthase, subunit alpha (trpA); The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.
 0.999
trpF
Phosphoribosyl anthranilate isomerase (trpF); Similar to PID:1054860 SP:Q56320 percent identity: 37.06; identified by sequence similarity; putative; Belongs to the TrpF family.
 
  
 0.999
trpG
Anthranilate synthase component II (trpG); Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high [...]
  
 0.999
trpCD
Anthranilate synthase component II (trpD); Bifunctional enzyme that catalyzes the second and fourth steps of tryptophan biosynthetic pathway. The second step is catalyzed by the anthranilate phosphoribosyltransferase, coded by the TrpD domain and the fourth step is catalyzed by indole-3-glycerol phosphate synthase, coded by the TrpC domain (By similarity).
  
 0.999
trpE
Anthranilate synthase component I (trpE) {Methanococcus jannaschii); Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly [...]
 
  
 0.998
trpB2
Tryptophan synthase, subunit beta (trpB-1); The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.
  
 
0.948
glyA
Serine hydroxymethyltransferase (glyA); Catalyzes the reversible interconversion of serine and glycine with tetrahydromethanopterin (H4MPT) serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro- aldol mechanism; Belongs to the SHMT family.
    
 0.944
AF_2138
Phosphoserine phosphatase (serB); Similar to GB:L77117 PID:1592204 percent identity: 50.71; identified by sequence similarity; putative; Belongs to the HAD-like hydrolase superfamily. SerB family.
  
 
 0.938
trpS
tryptophanyl-tRNA synthetase (trpS); Similar to GB:L77117 SP:Q58810 PID:1592065 percent identity: 52.41; identified by sequence similarity; putative; Belongs to the class-I aminoacyl-tRNA synthetase family.
     
 0.910
AF_2044
CDP-diacylglycerol--serine O-phosphatidyltransferase (pssA); Similar to GB:L77117 SP:Q58609 PID:1591841 percent identity: 36.65; identified by sequence similarity; putative.
     
  0.900
Your Current Organism:
Archaeoglobus fulgidus
NCBI taxonomy Id: 224325
Other names: A. fulgidus DSM 4304, Archaeoglobus fulgidus DSM 4304, Archaeoglobus fulgidus VC-16, Archaeoglobus fulgidus str. DSM 4304, Archaeoglobus fulgidus strain DSM 4304
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