| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AF_0580 | AF_2117 | AF_0580 | AF_2117 | Exodeoxyribonuclease III (xthA); Similar to PID:1653682 percent identity: 41.31; identified by sequence similarity; putative. | 3-methyladenine DNA glycosylase (alkA); Similar to GB:D14465 SP:P37878 PID:436209 GB:AL009126 percent identity: 30.05; identified by sequence similarity; putative. | 0.944 |
| AF_0580 | afung | AF_0580 | AF_2277 | Exodeoxyribonuclease III (xthA); Similar to PID:1653682 percent identity: 41.31; identified by sequence similarity; putative. | DNA polymerase, bacteriophage-type; Removes uracil bases that are present in DNA as a result of either deamination of cytosine or misincorporation of dUMP instead of dTMP. Can remove uracil from double-stranded DNA containing either a U/G or U/A base pair as well as from single-stranded DNA. | 0.554 |
| AF_0580 | fen | AF_0580 | AF_0264 | Exodeoxyribonuclease III (xthA); Similar to PID:1653682 percent identity: 41.31; identified by sequence similarity; putative. | DNA repair protein RAD2 (rad2); Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) [...] | 0.989 |
| AF_0580 | nth | AF_0580 | AF_1692 | Exodeoxyribonuclease III (xthA); Similar to PID:1653682 percent identity: 41.31; identified by sequence similarity; putative. | Endonuclease III (nth); DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. | 0.995 |
| AF_0580 | ogt | AF_0580 | AF_2314 | Exodeoxyribonuclease III (xthA); Similar to PID:1653682 percent identity: 41.31; identified by sequence similarity; putative. | methylated-DNA-protein-cysteine methyltransferase (ogt); Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. | 0.476 |
| AF_1039 | nth | AF_1039 | AF_1692 | Conserved hypothetical protein; Similar to GB:M20144 SP:P40403 PID:289302 GB:AL009126 percent identity: 26.56; identified by sequence similarity; putative. | Endonuclease III (nth); DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. | 0.704 |
| AF_1395 | fen | AF_1395 | AF_0264 | Conserved hypothetical protein; Similar to GB:L77117 PID:1592047 percent identity: 45.41; identified by sequence similarity; putative; In the N-terminal section; belongs to the UPF0200 family. | DNA repair protein RAD2 (rad2); Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) [...] | 0.609 |
| AF_1395 | nth | AF_1395 | AF_1692 | Conserved hypothetical protein; Similar to GB:L77117 PID:1592047 percent identity: 45.41; identified by sequence similarity; putative; In the N-terminal section; belongs to the UPF0200 family. | Endonuclease III (nth); DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. | 0.656 |
| AF_1395 | ogt | AF_1395 | AF_2314 | Conserved hypothetical protein; Similar to GB:L77117 PID:1592047 percent identity: 45.41; identified by sequence similarity; putative; In the N-terminal section; belongs to the UPF0200 family. | methylated-DNA-protein-cysteine methyltransferase (ogt); Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. | 0.413 |
| AF_1395 | purM | AF_1395 | AF_1693 | Conserved hypothetical protein; Similar to GB:L77117 PID:1592047 percent identity: 45.41; identified by sequence similarity; putative; In the N-terminal section; belongs to the UPF0200 family. | Phosphoribosylformylglycinamidine cyclo-ligase (purM); Similar to GB:L77117 SP:Q57656 PID:1590946 percent identity: 53.77; identified by sequence similarity; putative. | 0.571 |
| AF_1691 | nth | AF_1691 | AF_1692 | Predicted coding region AF_1691; Hypothetical protein; identified by GeneMark; putative. | Endonuclease III (nth); DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. | 0.784 |
| AF_1691 | purM | AF_1691 | AF_1693 | Predicted coding region AF_1691; Hypothetical protein; identified by GeneMark; putative. | Phosphoribosylformylglycinamidine cyclo-ligase (purM); Similar to GB:L77117 SP:Q57656 PID:1590946 percent identity: 53.77; identified by sequence similarity; putative. | 0.576 |
| AF_2117 | AF_0580 | AF_2117 | AF_0580 | 3-methyladenine DNA glycosylase (alkA); Similar to GB:D14465 SP:P37878 PID:436209 GB:AL009126 percent identity: 30.05; identified by sequence similarity; putative. | Exodeoxyribonuclease III (xthA); Similar to PID:1653682 percent identity: 41.31; identified by sequence similarity; putative. | 0.944 |
| AF_2117 | fen | AF_2117 | AF_0264 | 3-methyladenine DNA glycosylase (alkA); Similar to GB:D14465 SP:P37878 PID:436209 GB:AL009126 percent identity: 30.05; identified by sequence similarity; putative. | DNA repair protein RAD2 (rad2); Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) [...] | 0.630 |
| AF_2117 | nth | AF_2117 | AF_1692 | 3-methyladenine DNA glycosylase (alkA); Similar to GB:D14465 SP:P37878 PID:436209 GB:AL009126 percent identity: 30.05; identified by sequence similarity; putative. | Endonuclease III (nth); DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. | 0.637 |
| AF_2117 | ogt | AF_2117 | AF_2314 | 3-methyladenine DNA glycosylase (alkA); Similar to GB:D14465 SP:P37878 PID:436209 GB:AL009126 percent identity: 30.05; identified by sequence similarity; putative. | methylated-DNA-protein-cysteine methyltransferase (ogt); Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. | 0.711 |
| afung | AF_0580 | AF_2277 | AF_0580 | DNA polymerase, bacteriophage-type; Removes uracil bases that are present in DNA as a result of either deamination of cytosine or misincorporation of dUMP instead of dTMP. Can remove uracil from double-stranded DNA containing either a U/G or U/A base pair as well as from single-stranded DNA. | Exodeoxyribonuclease III (xthA); Similar to PID:1653682 percent identity: 41.31; identified by sequence similarity; putative. | 0.554 |
| afung | nth | AF_2277 | AF_1692 | DNA polymerase, bacteriophage-type; Removes uracil bases that are present in DNA as a result of either deamination of cytosine or misincorporation of dUMP instead of dTMP. Can remove uracil from double-stranded DNA containing either a U/G or U/A base pair as well as from single-stranded DNA. | Endonuclease III (nth); DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. | 0.916 |
| fen | AF_0580 | AF_0264 | AF_0580 | DNA repair protein RAD2 (rad2); Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) [...] | Exodeoxyribonuclease III (xthA); Similar to PID:1653682 percent identity: 41.31; identified by sequence similarity; putative. | 0.989 |
| fen | AF_1395 | AF_0264 | AF_1395 | DNA repair protein RAD2 (rad2); Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) [...] | Conserved hypothetical protein; Similar to GB:L77117 PID:1592047 percent identity: 45.41; identified by sequence similarity; putative; In the N-terminal section; belongs to the UPF0200 family. | 0.609 |
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