Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ilvHAcetolactate synthase, small subunit (ilvN); Similar to GB:L77117 SP:Q57625 PID:1590918 percent identity: 60.38; identified by sequence similarity; putative; Belongs to the acetolactate synthase small subunit family. (159 aa)    
Predicted Functional Partners:
AF_1720
Acetolactate synthase, large subunit (ilvB-1); Similar to GB:L77117 SP:Q57725 PID:1591003 percent identity: 57.48; identified by sequence similarity; putative.
 0.999
leuB
3-isopropylmalate dehydrogenase (leuB); Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity); Belongs to the isocitrate and isopropylmalate dehydrogenases family.
  
 0.996
ilvC
Ketol-acid reductoisomerase (ilvC); Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH or NADH to yield (R)-2,3-dihydroxy-isovalerate. It is able to use both NADPH and NADH, but has a preference for NADH.
 
 
 0.996
AF_1780
Acetolactate synthase, large subunit (ilvB-2); Similar to GB:L77117 SP:Q57725 PID:1591003 percent identity: 32.06; identified by sequence similarity; putative; Belongs to the TPP enzyme family.
 0.994
AF_2015
Acetolactate synthase, large subunit (ilvB-3); Similar to GB:L77117 SP:Q57725 PID:1591003 percent identity: 34.07; identified by sequence similarity; putative; Belongs to the TPP enzyme family.
 0.994
cimA
2-isopropylmalate synthase (leuA-1); Catalyzes the condensation of pyruvate and acetyl-coenzyme A to form (R)-citramalate; Belongs to the alpha-IPM synthase/homocitrate synthase family.
  
 
 0.976
leuA
2-isopropylmalate synthase (leuA-2); Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate).
  
 
 0.952
AF_2100
Acetolactate synthase, large subunit (ilvB-4); Similar to GB:L77117 SP:Q57725 PID:1591003 percent identity: 38.42; identified by sequence similarity; putative; Belongs to the TPP enzyme family.
 
 0.952
ilvD
Dihydroxy-acid dehydratase (ilvD); Similar to GB:L77117 PID:1591912 percent identity: 54.55; identified by sequence similarity; putative; Belongs to the IlvD/Edd family.
 
 
 0.949
korA
2-ketoglutarate ferredoxin oxidoreductase, subunit alpha (korA); Similar to GB:L77117 PID:1592279 percent identity: 52.34; identified by sequence similarity; putative.
  
 
 0.931
Your Current Organism:
Archaeoglobus fulgidus
NCBI taxonomy Id: 224325
Other names: A. fulgidus DSM 4304, Archaeoglobus fulgidus DSM 4304, Archaeoglobus fulgidus VC-16, Archaeoglobus fulgidus str. DSM 4304, Archaeoglobus fulgidus strain DSM 4304
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