Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
dacZConserved hypothetical protein; Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation. (334 aa)    
Predicted Functional Partners:
AF_0458
Phosphomannomutase (pmm); Similar to GB:L77117 PID:1591745 percent identity: 39.46; identified by sequence similarity; putative; Belongs to the phosphohexose mutase family.
   
 
 0.890
trpCD
Anthranilate synthase component II (trpD); Bifunctional enzyme that catalyzes the second and fourth steps of tryptophan biosynthetic pathway. The second step is catalyzed by the anthranilate phosphoribosyltransferase, coded by the TrpD domain and the fourth step is catalyzed by indole-3-glycerol phosphate synthase, coded by the TrpC domain (By similarity).
       0.812
AF_2029
Conserved hypothetical protein; Similar to GB:L77117 PID:1592223 percent identity: 39.41; identified by sequence similarity; putative.
 
   
 0.752
AF_1988
Conserved hypothetical protein; Similar to GB:L77117 SP:Q57692 PID:1499018 percent identity: 42.77; identified by sequence similarity; putative.
 
   
 0.616
AF_1760
Conserved hypothetical protein; Similar to GB:L77117 SP:Q57997 PID:1591284 percent identity: 34.04; identified by sequence similarity; putative.
     
 0.597
dphB
Diphthine synthase (dph5); S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.
  
   
 0.586
rpl37ae
LSU ribosomal protein L37AE (rpl37AE); Binds to the 23S rRNA.
  
   
 0.582
nadK
Conserved hypothetical protein; Involved in the regulation of the intracellular balance between NAD(H) and NADP(H), and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
     
 0.578
leuD2
3-isopropylmalate dehydratase, small subunit (leuD-2); Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily.
       0.572
AF_0820
Predicted coding region AF_0820; Hypothetical protein; identified by GeneMark; putative.
 
     0.569
Your Current Organism:
Archaeoglobus fulgidus
NCBI taxonomy Id: 224325
Other names: A. fulgidus DSM 4304, Archaeoglobus fulgidus DSM 4304, Archaeoglobus fulgidus VC-16, Archaeoglobus fulgidus str. DSM 4304, Archaeoglobus fulgidus strain DSM 4304
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