| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AF_1803 | AF_1805 | AF_1803 | AF_1805 | Conserved hypothetical protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Conserved hypothetical protein; Similar to GB:L77117 SP:Q57885 PID:1591147 percent identity: 48.52; identified by sequence similarity; putative. | 0.758 |
| AF_1803 | AF_2198 | AF_1803 | AF_2198 | Conserved hypothetical protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Conserved hypothetical protein; Similar to SP:Q10645 PID:1340100 percent identity: 23.28; identified by sequence similarity; putative. | 0.615 |
| AF_1803 | dphB | AF_1803 | AF_0381 | Conserved hypothetical protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Diphthine synthase (dph5); S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. | 0.918 |
| AF_1803 | fusA | AF_1803 | AF_1894 | Conserved hypothetical protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Translation elongation factor EF-2 (fus); Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity); Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor G [...] | 0.986 |
| AF_1803 | pcn | AF_1803 | AF_0335 | Conserved hypothetical protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Proliferating-cell nuclear antigen (pol30); Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family. | 0.680 |
| AF_1803 | rio1 | AF_1803 | AF_1804 | Conserved hypothetical protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Conserved hypothetical protein; Autophosphorylation of the rio1 protein is not necessary for maintenance of kinase activity. Prefers ATP over GTP. The yeast ortholog is involved in ribosome biogenesis. Despite the protein kinase domain is proposed to act predominantly as an ATPase (By similarity). | 0.733 |
| AF_1803 | rpl10e | AF_1803 | AF_1339 | Conserved hypothetical protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Ubiquinol-cytochrome C reductase complex, subunit VI requiring protein; Similar to GB:L77117 SP:Q57963 PID:1591247 percent identity: 60.95; identified by sequence similarity; putative; Belongs to the universal ribosomal protein uL16 family. | 0.733 |
| AF_1803 | rpl37ae | AF_1803 | AF_0057 | Conserved hypothetical protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | LSU ribosomal protein L37AE (rpl37AE); Binds to the 23S rRNA. | 0.648 |
| AF_1803 | rps4e | AF_1803 | AF_1913 | Conserved hypothetical protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | SSU ribosomal protein S4E (rps4E); Similar to GB:L77117 SP:P54039 PID:1591170 percent identity: 48.92; identified by sequence similarity; putative; Belongs to the eukaryotic ribosomal protein eS4 family. | 0.614 |
| AF_1803 | topA | AF_1803 | AF_1806 | Conserved hypothetical protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | DNA topoisomerase I (topA); Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing D [...] | 0.638 |
| AF_1805 | AF_1803 | AF_1805 | AF_1803 | Conserved hypothetical protein; Similar to GB:L77117 SP:Q57885 PID:1591147 percent identity: 48.52; identified by sequence similarity; putative. | Conserved hypothetical protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | 0.758 |
| AF_1805 | dphB | AF_1805 | AF_0381 | Conserved hypothetical protein; Similar to GB:L77117 SP:Q57885 PID:1591147 percent identity: 48.52; identified by sequence similarity; putative. | Diphthine synthase (dph5); S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. | 0.568 |
| AF_1805 | rio1 | AF_1805 | AF_1804 | Conserved hypothetical protein; Similar to GB:L77117 SP:Q57885 PID:1591147 percent identity: 48.52; identified by sequence similarity; putative. | Conserved hypothetical protein; Autophosphorylation of the rio1 protein is not necessary for maintenance of kinase activity. Prefers ATP over GTP. The yeast ortholog is involved in ribosome biogenesis. Despite the protein kinase domain is proposed to act predominantly as an ATPase (By similarity). | 0.937 |
| AF_1805 | rpl37ae | AF_1805 | AF_0057 | Conserved hypothetical protein; Similar to GB:L77117 SP:Q57885 PID:1591147 percent identity: 48.52; identified by sequence similarity; putative. | LSU ribosomal protein L37AE (rpl37AE); Binds to the 23S rRNA. | 0.438 |
| AF_1805 | rps4e | AF_1805 | AF_1913 | Conserved hypothetical protein; Similar to GB:L77117 SP:Q57885 PID:1591147 percent identity: 48.52; identified by sequence similarity; putative. | SSU ribosomal protein S4E (rps4E); Similar to GB:L77117 SP:P54039 PID:1591170 percent identity: 48.92; identified by sequence similarity; putative; Belongs to the eukaryotic ribosomal protein eS4 family. | 0.919 |
| AF_1805 | topA | AF_1805 | AF_1806 | Conserved hypothetical protein; Similar to GB:L77117 SP:Q57885 PID:1591147 percent identity: 48.52; identified by sequence similarity; putative. | DNA topoisomerase I (topA); Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing D [...] | 0.775 |
| AF_2198 | AF_1803 | AF_2198 | AF_1803 | Conserved hypothetical protein; Similar to SP:Q10645 PID:1340100 percent identity: 23.28; identified by sequence similarity; putative. | Conserved hypothetical protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | 0.615 |
| AF_2198 | fusA | AF_2198 | AF_1894 | Conserved hypothetical protein; Similar to SP:Q10645 PID:1340100 percent identity: 23.28; identified by sequence similarity; putative. | Translation elongation factor EF-2 (fus); Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity); Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor G [...] | 0.418 |
| AF_2198 | pcn | AF_2198 | AF_0335 | Conserved hypothetical protein; Similar to SP:Q10645 PID:1340100 percent identity: 23.28; identified by sequence similarity; putative. | Proliferating-cell nuclear antigen (pol30); Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family. | 0.465 |
| AF_2198 | rps4e | AF_2198 | AF_1913 | Conserved hypothetical protein; Similar to SP:Q10645 PID:1340100 percent identity: 23.28; identified by sequence similarity; putative. | SSU ribosomal protein S4E (rps4E); Similar to GB:L77117 SP:P54039 PID:1591170 percent identity: 48.92; identified by sequence similarity; putative; Belongs to the eukaryotic ribosomal protein eS4 family. | 0.917 |
STRING v12.5 is now available!
