Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
mchN5,N10-methenyltetrahydromethanopterin cyclohydrolase (mch); Catalyzes the hydrolysis of methenyl-H(4)MPT(+) to 5-formyl- H(4)MPT; Belongs to the MCH family. (316 aa)    
Predicted Functional Partners:
ftr
Formylmethanofuran:tetrahydromethanopterin formyltransferase (ftr-2); Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT).
 
 
 0.994
AF_2073
Formylmethanofuran:tetrahydromethanopterin formyltransferase (ftr-1); Similar to GB:X70784 PID:452327 SP:Q49168 percent identity: 45.97; identified by sequence similarity; putative; Belongs to the FTR family.
 
 
 0.990
mtd
N5,N10-methylenetetrahydromethanopterin dehydrogenase (mtd); Catalyzes the oxidation of methylene-H(4)MPT to methenyl- H(4)MPT(+); Belongs to the MTD family.
    
 0.979
AF_1931
Tungsten formylmethanofuran dehydrogenase, subunit C (fwdC); Similar to GB:L77117 PID:1591797 percent identity: 44.09; identified by sequence similarity; putative.
   
 0.934
fae-hps
D-arabino 3-hexulose 6-phosphate formaldehyde lyase (hps-2); Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10- methylenetetrahydromethanopterin; In the C-terminal section; belongs to the HPS/KGPDC family. HPS subfamily.
 
   
 0.883
AF_1930
Tungsten formylmethanofuran dehydrogenase, subunit A (fwdA); Similar to GB:L77117 PID:1591795 percent identity: 48.91; identified by sequence similarity; putative.
 
   
 0.871
mer
N5,N10-methylenetetrahydromethanopterin reductase (mer-1); Catalyzes the oxidation of methyl-H(4)MPT to methylene- H(4)MPT; Belongs to the mer family.
  
   
 0.799
AF_2089
Conserved hypothetical protein; Catalyzes the condensation of 4-aminobenzoate (pABA) with 5- phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta- ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P).
 
   
 0.769
AF_1928
Tungsten formylmethanofuran dehydrogenase, subunit D (fwdD-2); Similar to GB:L77117 PID:1591794 percent identity: 52.59; identified by sequence similarity; putative.
 
   
 0.761
AF_1835
Conserved hypothetical protein; Similar to GB:L77117 SP:Q57680 PID:1499004 percent identity: 33.08; identified by sequence similarity; putative.
 
     0.757
Your Current Organism:
Archaeoglobus fulgidus
NCBI taxonomy Id: 224325
Other names: A. fulgidus DSM 4304, Archaeoglobus fulgidus DSM 4304, Archaeoglobus fulgidus VC-16, Archaeoglobus fulgidus str. DSM 4304, Archaeoglobus fulgidus strain DSM 4304
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.