Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
AF_1952Conserved hypothetical protein; Similar to GB:Z19055 SP:P42394 PID:396660 percent identity: 22.87; identified by sequence similarity; putative. (238 aa)    
Predicted Functional Partners:
topA
DNA topoisomerase I (topA); Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing D [...]
 
     0.709
hisI
phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphohydrolase (hisIE); Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
       0.703
AF_1951
Conserved hypothetical protein; Similar to GB:L77117 PID:1592164 percent identity: 51.20; identified by sequence similarity; putative.
       0.703
AF_0782
Predicted coding region AF_0782; Hypothetical protein; identified by GeneMark; putative.
  
     0.697
AF_1532
Conserved hypothetical protein; Similar to GB:L77117 PID:1591589 percent identity: 41.27; identified by sequence similarity; putative.
  
     0.678
AF_0779
Predicted coding region AF_0779; Hypothetical protein; identified by GeneMark; putative.
  
     0.675
AF_0780
Predicted coding region AF_0780; Hypothetical protein; identified by GeneMark; putative.
  
     0.667
AF_1791
Signal sequence peptidase (sec11); Similar to GB:Z47047 SP:P15367 PID:4433 PID:557828 PID:763367 percent identity: 36.30; identified by sequence similarity; putative.
  
     0.667
AF_0995
Conserved hypothetical protein; Similar to GB:L77117 PID:1591923 percent identity: 26.90; identified by sequence similarity; putative.
  
     0.646
aglB3
Transmembrane oligosaccharyl transferase, putative; Oligosaccharyl transferase (OST) that catalyzes the initial transfer of a defined glycan (a glucose-linked heptasaccharide composed of 3 Glc, 2 Man, 2 Gal and a sulfate for A.fulgidus AglB-L) from the lipid carrier dolichol-monophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation; Belongs to the STT3 family.
  
     0.639
Your Current Organism:
Archaeoglobus fulgidus
NCBI taxonomy Id: 224325
Other names: A. fulgidus DSM 4304, Archaeoglobus fulgidus DSM 4304, Archaeoglobus fulgidus VC-16, Archaeoglobus fulgidus str. DSM 4304, Archaeoglobus fulgidus strain DSM 4304
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