| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AF_0116 | AF_0727 | AF_0116 | AF_0727 | Uroporphyrinogen III synthase (hemD); Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Cobalamin biosynthesis precorrin-2 methyltransferase (cbiL); Similar to PID:1652770 percent identity: 31.46; identified by sequence similarity; putative; Belongs to the precorrin methyltransferase family. | 0.436 |
| AF_0116 | AF_1980 | AF_0116 | AF_1980 | Uroporphyrinogen III synthase (hemD); Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Heme exporter protein C (helC); Similar to SP:P29961 GB:X63462 PID:46026 percent identity: 29.02; identified by sequence similarity; putative. | 0.744 |
| AF_0116 | cbiA | AF_0116 | AF_2229 | Uroporphyrinogen III synthase (hemD); Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Cobyrinic acid a,c-diamide synthase (cbiA); Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | 0.556 |
| AF_0116 | cbiHC | AF_0116 | AF_0724 | Uroporphyrinogen III synthase (hemD); Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Cobalamin biosynthesis precorrin-3 methylase (cbiH); Bifunctional enzyme with a methyltransferase domain that catalyzes the ring contraction and methylation of C-17 in cobalt-factor III to form cobalt-factor IV, and an isomerase domain that catalyzes the conversion of cobalt-precorrin-8 to cobyrinate; In the C-terminal section; belongs to the CobH family. | 0.925 |
| AF_0116 | cbiX | AF_0116 | AF_0721 | Uroporphyrinogen III synthase (hemD); Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Conserved hypothetical protein; Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Belongs to the CbiX family. CbiXS subfamily. | 0.643 |
| AF_0116 | hemA | AF_0116 | AF_1975 | Uroporphyrinogen III synthase (hemD); Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | glutamyl-tRNA reductase (hemA); Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.808 |
| AF_0116 | hemB | AF_0116 | AF_1974 | Uroporphyrinogen III synthase (hemD); Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Porphobilinogen synthase (hemB); Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity). | 0.950 |
| AF_0116 | hemC | AF_0116 | AF_1242 | Uroporphyrinogen III synthase (hemD); Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Porphobilinogen deaminase (hemC); Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. | 0.997 |
| AF_0116 | hemL | AF_0116 | AF_1241 | Uroporphyrinogen III synthase (hemD); Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Glutamate-1-semialdehyde aminotransferase (hemL); Similar to GB:L77117 SP:Q58020 PID:1591312 percent identity: 54.31; identified by sequence similarity; putative; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily. | 0.737 |
| AF_0727 | AF_0116 | AF_0727 | AF_0116 | Cobalamin biosynthesis precorrin-2 methyltransferase (cbiL); Similar to PID:1652770 percent identity: 31.46; identified by sequence similarity; putative; Belongs to the precorrin methyltransferase family. | Uroporphyrinogen III synthase (hemD); Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.436 |
| AF_0727 | cbiA | AF_0727 | AF_2229 | Cobalamin biosynthesis precorrin-2 methyltransferase (cbiL); Similar to PID:1652770 percent identity: 31.46; identified by sequence similarity; putative; Belongs to the precorrin methyltransferase family. | Cobyrinic acid a,c-diamide synthase (cbiA); Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | 0.825 |
| AF_0727 | cbiHC | AF_0727 | AF_0724 | Cobalamin biosynthesis precorrin-2 methyltransferase (cbiL); Similar to PID:1652770 percent identity: 31.46; identified by sequence similarity; putative; Belongs to the precorrin methyltransferase family. | Cobalamin biosynthesis precorrin-3 methylase (cbiH); Bifunctional enzyme with a methyltransferase domain that catalyzes the ring contraction and methylation of C-17 in cobalt-factor III to form cobalt-factor IV, and an isomerase domain that catalyzes the conversion of cobalt-precorrin-8 to cobyrinate; In the C-terminal section; belongs to the CobH family. | 0.999 |
| AF_0727 | cbiX | AF_0727 | AF_0721 | Cobalamin biosynthesis precorrin-2 methyltransferase (cbiL); Similar to PID:1652770 percent identity: 31.46; identified by sequence similarity; putative; Belongs to the precorrin methyltransferase family. | Conserved hypothetical protein; Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Belongs to the CbiX family. CbiXS subfamily. | 0.991 |
| AF_0727 | hemA | AF_0727 | AF_1975 | Cobalamin biosynthesis precorrin-2 methyltransferase (cbiL); Similar to PID:1652770 percent identity: 31.46; identified by sequence similarity; putative; Belongs to the precorrin methyltransferase family. | glutamyl-tRNA reductase (hemA); Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.644 |
| AF_0727 | hemB | AF_0727 | AF_1974 | Cobalamin biosynthesis precorrin-2 methyltransferase (cbiL); Similar to PID:1652770 percent identity: 31.46; identified by sequence similarity; putative; Belongs to the precorrin methyltransferase family. | Porphobilinogen synthase (hemB); Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity). | 0.467 |
| AF_0727 | hemC | AF_0727 | AF_1242 | Cobalamin biosynthesis precorrin-2 methyltransferase (cbiL); Similar to PID:1652770 percent identity: 31.46; identified by sequence similarity; putative; Belongs to the precorrin methyltransferase family. | Porphobilinogen deaminase (hemC); Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. | 0.490 |
| AF_0727 | hemL | AF_0727 | AF_1241 | Cobalamin biosynthesis precorrin-2 methyltransferase (cbiL); Similar to PID:1652770 percent identity: 31.46; identified by sequence similarity; putative; Belongs to the precorrin methyltransferase family. | Glutamate-1-semialdehyde aminotransferase (hemL); Similar to GB:L77117 SP:Q58020 PID:1591312 percent identity: 54.31; identified by sequence similarity; putative; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily. | 0.465 |
| AF_1980 | AF_0116 | AF_1980 | AF_0116 | Heme exporter protein C (helC); Similar to SP:P29961 GB:X63462 PID:46026 percent identity: 29.02; identified by sequence similarity; putative. | Uroporphyrinogen III synthase (hemD); Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.744 |
| AF_1980 | hemA | AF_1980 | AF_1975 | Heme exporter protein C (helC); Similar to SP:P29961 GB:X63462 PID:46026 percent identity: 29.02; identified by sequence similarity; putative. | glutamyl-tRNA reductase (hemA); Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.742 |
| AF_1980 | hemB | AF_1980 | AF_1974 | Heme exporter protein C (helC); Similar to SP:P29961 GB:X63462 PID:46026 percent identity: 29.02; identified by sequence similarity; putative. | Porphobilinogen synthase (hemB); Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity). | 0.628 |
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