STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pan26S protease regulatory subunit 4; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-2 [...] (398 aa)    
Predicted Functional Partners:
psmA
Proteasome, subunit alpha (psmA); Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
 0.999
psmB
Proteasome, subunit beta (psmB); Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
  
 0.998
AF_2198
Conserved hypothetical protein; Similar to SP:Q10645 PID:1340100 percent identity: 23.28; identified by sequence similarity; putative.
  
 0.998
AF_0866
Glycerol kinase (glpK); Similar to GB:M34393 SP:P18157 PID:142992 PID:2226137 GB:AL009126 percent identity: 33.83; identified by sequence similarity; putative; Belongs to the FGGY kinase family.
 
 0.997
rpl40e
LSU ribosomal protein L40E (rpl40E); Similar to GB:L77117 SP:P54058 PID:1591423 percent identity: 73.33; identified by sequence similarity; putative; Belongs to the eukaryotic ribosomal protein eL40 family.
  
 0.953
AF_1977
Conserved hypothetical protein; Similar to GB:L77117 SP:Q58006 PID:1591294 percent identity: 38.46; identified by sequence similarity; putative.
 
   0.831
rad50
Purine NTPase, putative; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex; Belongs to the SMC family. RAD50 subfamily.
   
 
 0.784
AF_1420
Membrane protein; Similar to GB:L77117 SP:Q58237 PID:1591514 percent identity: 51.83; identified by sequence similarity; putative.
   
 
 0.736
AF_0477
AAA superfamily ATPase; Similar to GB:D78275 SP:Q92524 PID:1526426 PID:2213932 percent identity: 34.97; identified by sequence similarity; putative; Belongs to the AAA ATPase family.
 
0.692
alaS
alanyl-tRNA synthetase (alaS); Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Incorrectly charged aminoacyl-tRNA(Ala) is also edited in situ by the editing domain.
  
 0.663
Your Current Organism:
Archaeoglobus fulgidus
NCBI taxonomy Id: 224325
Other names: A. fulgidus DSM 4304, Archaeoglobus fulgidus DSM 4304, Archaeoglobus fulgidus VC-16, Archaeoglobus fulgidus str. DSM 4304, Archaeoglobus fulgidus strain DSM 4304
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.