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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cutAPeriplasmic divalent cation tolerance protein (cutA); Involved in resistance toward heavy metals. (102 aa)    
Predicted Functional Partners:
AF_1979
Conserved hypothetical protein; Similar to GP:1707808 percent identity: 44.92; identified by sequence similarity; putative.
       0.847
cbiM
Cobalamin biosynthesis protein (cbiM-1); Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.
      
 0.846
cbiN
Cobalt transport protein (cbiN); Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import; Belongs to the CbiN family.
      
 0.839
AF_1977
Conserved hypothetical protein; Similar to GB:L77117 SP:Q58006 PID:1591294 percent identity: 38.46; identified by sequence similarity; putative.
  
    0.711
AF_1322
Conserved hypothetical protein; Similar to GB:L77117 PID:1591634 percent identity: 33.23; identified by sequence similarity; putative.
       0.657
trpCD
Anthranilate synthase component II (trpD); Bifunctional enzyme that catalyzes the second and fourth steps of tryptophan biosynthetic pathway. The second step is catalyzed by the anthranilate phosphoribosyltransferase, coded by the TrpD domain and the fourth step is catalyzed by indole-3-glycerol phosphate synthase, coded by the TrpC domain (By similarity).
     
 0.551
trpF
Phosphoribosyl anthranilate isomerase (trpF); Similar to PID:1054860 SP:Q56320 percent identity: 37.06; identified by sequence similarity; putative; Belongs to the TrpF family.
     
 0.525
AF_0344
Desulfoferrodoxin, putative; Uses electrons from reduced NADP, by way of rubredoxin and an oxidoreductase, to catalyze the reduction of superoxide to hydrogen peroxide.
  
    0.500
AF_0833
Desulfoferrodoxin (dfx); Similar to GB:M81168 SP:P20418 GB:M28848 PID:145115 PID:758676 percent identity: 63.03; identified by sequence similarity; putative; Belongs to the desulfoferrodoxin family.
  
    0.500
pan
26S protease regulatory subunit 4; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-2 [...]
       0.500
Your Current Organism:
Archaeoglobus fulgidus
NCBI taxonomy Id: 224325
Other names: A. fulgidus DSM 4304, Archaeoglobus fulgidus DSM 4304, Archaeoglobus fulgidus VC-16, Archaeoglobus fulgidus str. DSM 4304, Archaeoglobus fulgidus strain DSM 4304
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