Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
AF_1979Conserved hypothetical protein; Similar to GP:1707808 percent identity: 44.92; identified by sequence similarity; putative. (252 aa)    
Predicted Functional Partners:
cutA
Periplasmic divalent cation tolerance protein (cutA); Involved in resistance toward heavy metals.
       0.872
AF_1322
Conserved hypothetical protein; Similar to GB:L77117 PID:1591634 percent identity: 33.23; identified by sequence similarity; putative.
       0.855
AF_1977
Conserved hypothetical protein; Similar to GB:L77117 SP:Q58006 PID:1591294 percent identity: 38.46; identified by sequence similarity; putative.
       0.682
AF_1217
Conserved hypothetical protein; Similar to GB:L77117 SP:Q60332 PID:1498780 percent identity: 39.94; identified by sequence similarity; putative.
       0.516
pan
26S protease regulatory subunit 4; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-2 [...]
       0.488
Your Current Organism:
Archaeoglobus fulgidus
NCBI taxonomy Id: 224325
Other names: A. fulgidus DSM 4304, Archaeoglobus fulgidus DSM 4304, Archaeoglobus fulgidus VC-16, Archaeoglobus fulgidus str. DSM 4304, Archaeoglobus fulgidus strain DSM 4304
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