Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
AF_1984Iron-dependent repressor (troR); Similar to GP:1777937 percent identity: 28.35; identified by sequence similarity; putative. (139 aa)    
Predicted Functional Partners:
AF_1981
ABC transporter, permease protein; Similar to GB:L11577 SP:P42361 percent identity: 29.88; identified by sequence similarity; putative.
 
  
 0.965
AF_1982
ABC transporter, ATP-binding protein; Similar to GP:1777934 percent identity: 41.30; identified by sequence similarity; putative.
  
  
 0.934
AF_1983
ABC transporter, periplasmic binding protein; Similar to GP:1777933 percent identity: 25.39; identified by sequence similarity; putative.
  
  
 0.860
AF_0245
Iron-dependent repressor (desR); Similar to PID:899417 percent identity: 28.18; identified by sequence similarity; putative.
 
   
 0.694
AF_1980
Heme exporter protein C (helC); Similar to SP:P29961 GB:X63462 PID:46026 percent identity: 29.02; identified by sequence similarity; putative.
     
 0.664
ilvC
Ketol-acid reductoisomerase (ilvC); Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH or NADH to yield (R)-2,3-dihydroxy-isovalerate. It is able to use both NADPH and NADH, but has a preference for NADH.
     
 0.598
AF_1785
Iron-dependent repressor; Similar to GB:L77117 SP:Q57988 PID:1592296 percent identity: 41.96; identified by sequence similarity; putative.
 
   
 0.539
AF_0154
Conserved hypothetical protein; Similar to GP:1787253 percent identity: 28.11; identified by sequence similarity; putative.
     
 0.513
cbiA
Cobyrinic acid a,c-diamide synthase (cbiA); Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family.
  
   
 0.484
AF_2127
Transcriptional regulatory protein, LysR family; Similar to GB:L77117 SP:Q57748 PID:1591023 percent identity: 30.80; identified by sequence similarity; putative.
 
 
 0.471
Your Current Organism:
Archaeoglobus fulgidus
NCBI taxonomy Id: 224325
Other names: A. fulgidus DSM 4304, Archaeoglobus fulgidus DSM 4304, Archaeoglobus fulgidus VC-16, Archaeoglobus fulgidus str. DSM 4304, Archaeoglobus fulgidus strain DSM 4304
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