Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
AF_2138Phosphoserine phosphatase (serB); Similar to GB:L77117 PID:1592204 percent identity: 50.71; identified by sequence similarity; putative; Belongs to the HAD-like hydrolase superfamily. SerB family. (344 aa)    
Predicted Functional Partners:
trpCD
Anthranilate synthase component II (trpD); Bifunctional enzyme that catalyzes the second and fourth steps of tryptophan biosynthetic pathway. The second step is catalyzed by the anthranilate phosphoribosyltransferase, coded by the TrpD domain and the fourth step is catalyzed by indole-3-glycerol phosphate synthase, coded by the TrpC domain (By similarity).
     
 0.977
glyA
Serine hydroxymethyltransferase (glyA); Catalyzes the reversible interconversion of serine and glycine with tetrahydromethanopterin (H4MPT) serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro- aldol mechanism; Belongs to the SHMT family.
  
 0.957
trpB1
Tryptophan synthase, subunit beta (trpB-2); The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.
  
 
 0.941
AF_2031
Predicted coding region AF_2031; Hypothetical protein; identified by GeneMark; putative.
    
 0.941
trpA
Tryptophan synthase, subunit alpha (trpA); The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.
    
 0.915
AF_1422
Aspartate racemase; Similar to GP:1545809 percent identity: 28.02; identified by sequence similarity; putative.
    
 0.912
trpB2
Tryptophan synthase, subunit beta (trpB-1); The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.
    
 0.906
hisF
Imidazoleglycerol-phosphate synthase, cyclase subunit (hisF); IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity).
  
  
 0.893
hisB
Imidazoleglycerol-phosphate dehydrogenase/histidinol-phosphatase (hisB); Similar to GB:L77117 SP:Q58109 PID:1591413 percent identity: 42.24; identified by sequence similarity; putative.
  
  
 0.873
hisI
phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphohydrolase (hisIE); Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
  
  
 0.860
Your Current Organism:
Archaeoglobus fulgidus
NCBI taxonomy Id: 224325
Other names: A. fulgidus DSM 4304, Archaeoglobus fulgidus DSM 4304, Archaeoglobus fulgidus VC-16, Archaeoglobus fulgidus str. DSM 4304, Archaeoglobus fulgidus strain DSM 4304
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