Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
AF_2144Thioredoxin (trx-4); Similar to SP:P37395 percent identity: 48.94; identified by sequence similarity; putative. (105 aa)    
Predicted Functional Partners:
AF_1554
Thioredoxin reductase (trxB); Similar to PID:1171125 SP:P52213 percent identity: 45.21; identified by sequence similarity; putative.
 
 0.867
AF_0270
Alkyl hydroperoxide reductase; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.
  
 0.851
AF_2220
Predicted coding region AF_2220; Hypothetical protein; identified by GeneMark; putative.
  
 0.837
AF_2143
Conserved hypothetical protein; Similar to GB:L77117 PID:1500391 percent identity: 30.36; identified by sequence similarity; putative.
       0.787
AF_2141
Predicted coding region AF_2141; Hypothetical protein; identified by GeneMark; putative.
       0.778
AF_2145
Glutaredoxin (grx-2); Acts to maintain redox homeostasis; functions as a protein disulfide reductase; Belongs to the glutaredoxin family.
       0.775
copA
Cation-transporting ATPase, P-type (pacS); Probably involved in copper and silver export.
     
 0.645
secG
Predicted coding region AF_1776; Involved in protein export. The function of the beta subunit is unknown, but it may be involved in stabilization of the trimeric complex (By similarity).
       0.624
AF_2146
GTP-binding protein; Similar to GB:L77117 PID:1591967 percent identity: 65.91; identified by sequence similarity; putative.
   
   0.603
AF_0474
Transcriptional regulatory protein, AsnC family; Similar to SP:P42180 percent identity: 36.84; identified by sequence similarity; putative.
       0.576
Your Current Organism:
Archaeoglobus fulgidus
NCBI taxonomy Id: 224325
Other names: A. fulgidus DSM 4304, Archaeoglobus fulgidus DSM 4304, Archaeoglobus fulgidus VC-16, Archaeoglobus fulgidus str. DSM 4304, Archaeoglobus fulgidus strain DSM 4304
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