Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
AF_2184Conserved hypothetical protein; Similar to PID:1653500 percent identity: 33.33; identified by sequence similarity; putative. (208 aa)    
Predicted Functional Partners:
sucD2
succinyl-CoA synthetase, alpha subunit (sucD-2); Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
       0.773
sucC2
succinyl-CoA synthetase, beta subunit (sucC-2); Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
       0.773
AF_2183
Predicted coding region AF_2183; Hypothetical protein; identified by GeneMark; putative.
       0.689
AF_1030
Conserved hypothetical protein; Similar to GB:L77117 SP:Q58824 PID:1592079 percent identity: 45.44; identified by sequence similarity; putative.
 
     0.670
AF_0748
Predicted coding region AF_0748; Hypothetical protein; identified by GeneMark; putative.
  
  
 0.592
nadK
Conserved hypothetical protein; Involved in the regulation of the intracellular balance between NAD(H) and NADP(H), and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
  
  
 0.592
AF_2187
Predicted coding region AF_2187; Hypothetical protein; identified by GeneMark; putative.
       0.584
AF_2182
Conserved hypothetical protein; Similar to GP:1707766 percent identity: 39.76; identified by sequence similarity; putative.
       0.559
AF_0248
NADH-dependent flavin oxidoreductase; Similar to SP:P54550 PID:1303964 GB:AL009126 percent identity: 36.73; identified by sequence similarity; putative.
       0.533
AF_2163
Predicted coding region AF_2163; Hypothetical protein; identified by GeneMark; putative.
  
     0.512
Your Current Organism:
Archaeoglobus fulgidus
NCBI taxonomy Id: 224325
Other names: A. fulgidus DSM 4304, Archaeoglobus fulgidus DSM 4304, Archaeoglobus fulgidus VC-16, Archaeoglobus fulgidus str. DSM 4304, Archaeoglobus fulgidus strain DSM 4304
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.