Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
sucD2succinyl-CoA synthetase, alpha subunit (sucD-2); Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (287 aa)    
Predicted Functional Partners:
sucC1
succinyl-CoA synthetase, beta subunit (sucC-1); Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
 0.999
sucC2
succinyl-CoA synthetase, beta subunit (sucC-2); Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
 0.999
AF_0682
Succinate dehydrogenase, iron-sulfur subunit B (sdhB); Similar to GB:X70908 PID:396212 percent identity: 51.27; identified by sequence similarity; putative.
 
 0.990
AF_0681
Succinate dehydrogenase, flavoprotein subunit A (sdhA); Similar to GP:1524302 percent identity: 48.23; identified by sequence similarity; putative.
 
 0.982
AF_0683
Succinate dehydrogenase, subunit C (sdhC); Similar to GP:1524299 percent identity: 36.56; identified by sequence similarity; putative.
  
 
 0.981
korB
2-ketoglutarate ferredoxin oxidoreductase, subunit beta (korB); Similar to GB:L77117 PID:1591241 percent identity: 51.38; identified by sequence similarity; putative.
  
 
 0.957
sdhD
Succinate dehydrogenase, subunit D (sdhD); Membrane-anchoring subunit of succinate dehydrogenase (SDH).
  
 
 0.949
korA
2-ketoglutarate ferredoxin oxidoreductase, subunit alpha (korA); Similar to GB:L77117 PID:1592279 percent identity: 52.34; identified by sequence similarity; putative.
    
 0.927
AF_2219
methylmalonyl-CoA mutase, subunit alpha, C-terminus (mcmA2); Similar to GB:L30136 PID:463175 percent identity: 48.72; identified by sequence similarity; putative.
    
 0.920
AF_0750
2-oxoacid ferredoxin oxidoreductase, subunit beta (orB); Similar to GP:1565184 percent identity: 49.21; identified by sequence similarity; putative.
  
 
 0.919
Your Current Organism:
Archaeoglobus fulgidus
NCBI taxonomy Id: 224325
Other names: A. fulgidus DSM 4304, Archaeoglobus fulgidus DSM 4304, Archaeoglobus fulgidus VC-16, Archaeoglobus fulgidus str. DSM 4304, Archaeoglobus fulgidus strain DSM 4304
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