Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
AF_2217methylmalonyl-CoA decarboxylase, subunit alpha (mmdA); Similar to GB:L22208 GB:Z24754 PID:415593 PID:415915 percent identity: 62.52; identified by sequence similarity; putative. (516 aa)    
Predicted Functional Partners:
pycA
Biotin carboxylase (acc); Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.
 
 
 0.978
AF_0074
Biotin operon repressor/biotin--[acetyl CoA carboxylase] ligase (birA); Similar to SP:P42975 PID:1146239 PID:755608 PID:773349 GB:AL009126 percent identity: 36.59; identified by sequence similarity; putative.
 
 
 0.897
AF_2218
Conserved hypothetical protein; Similar to SP:P54540 PID:1303954 GB:AL009126 percent identity: 40.00; identified by sequence similarity; putative.
 
  
 0.884
AF_2219
methylmalonyl-CoA mutase, subunit alpha, C-terminus (mcmA2); Similar to GB:L30136 PID:463175 percent identity: 48.72; identified by sequence similarity; putative.
  
  
 0.880
AF_2216
methylmalonyl-CoA decarboxylase, biotin carboxyl carrier subunit (mmdC); Similar to GB:L22208 GB:Z24754 PID:415596 PID:415918 percent identity: 36.22; identified by sequence similarity; putative.
 
  
 0.798
AF_1340
Citrate synthase (citZ); Similar to GB:U05257 SP:P39120 PID:487433 PID:2293267 GB:AL009126 percent identity: 50.27; identified by sequence similarity; putative.
  
 
 0.756
AF_2215
methylmalonyl-CoA mutase, subunit alpha, N-terminus (mcmA1); Similar to SP:P11653 PID:581476 percent identity: 51.18; identified by sequence similarity; putative.
  
  
 0.728
mdh
L-malate dehydrogenase, NAD+-dependent (mdhA); Catalyzes the reversible oxidation of malate to oxaloacetate. Can also oxidize tartrate.
  
  
 0.699
AF_2084
Oxaloacetate decarboxylase, sodium ion pump subunit (oadB); Similar to GB:M96434 SP:Q03031 PID:154198 percent identity: 59.83; identified by sequence similarity; putative.
  
  
 0.699
AF_2220
Predicted coding region AF_2220; Hypothetical protein; identified by GeneMark; putative.
  
  
 0.661
Your Current Organism:
Archaeoglobus fulgidus
NCBI taxonomy Id: 224325
Other names: A. fulgidus DSM 4304, Archaeoglobus fulgidus DSM 4304, Archaeoglobus fulgidus VC-16, Archaeoglobus fulgidus str. DSM 4304, Archaeoglobus fulgidus strain DSM 4304
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