Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
cbiACobyrinic acid a,c-diamide synthase (cbiA); Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. (458 aa)    
Predicted Functional Partners:
cbiHC
Cobalamin biosynthesis precorrin-3 methylase (cbiH); Bifunctional enzyme with a methyltransferase domain that catalyzes the ring contraction and methylation of C-17 in cobalt-factor III to form cobalt-factor IV, and an isomerase domain that catalyzes the conversion of cobalt-precorrin-8 to cobyrinate; In the C-terminal section; belongs to the CobH family.
 
 
 0.999
cobQ
Cobyric acid synthase (cbiP); Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity); Belongs to the CobB/CobQ family. CobQ subfamily.
  
 0.990
AF_0725
Cobalamin biosynthesis precorrin methylase (cbiG); Similar to PID:1651952 percent identity: 30.69; identified by sequence similarity; putative.
 
  
 0.938
AF_0726
Cobalamin biosynthesis precorrin-3 methylase (cbiF); Similar to GB:L77117 PID:1500473 percent identity: 49.16; identified by sequence similarity; putative.
  
 0.937
AF_1290
Conserved hypothetical protein; Similar to SP:P45515 PID:493088 percent identity: 31.54; identified by sequence similarity; putative.
    
 0.931
hisC2
Histidinol-phosphate aminotransferase (hisC-2); Similar to GB:L77117 PID:1591622 percent identity: 36.83; identified by sequence similarity; putative.
 
  
 0.922
cbiD
Cobalamin biosynthesis protein (cbiD); Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.
 
  
 0.920
AF_0727
Cobalamin biosynthesis precorrin-2 methyltransferase (cbiL); Similar to PID:1652770 percent identity: 31.46; identified by sequence similarity; putative; Belongs to the precorrin methyltransferase family.
 
  
 0.913
cobD
Cobalamin biosynthesis protein (cbiB); Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
  
 0.913
cbiX
Conserved hypothetical protein; Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Belongs to the CbiX family. CbiXS subfamily.
     
 0.901
Your Current Organism:
Archaeoglobus fulgidus
NCBI taxonomy Id: 224325
Other names: A. fulgidus DSM 4304, Archaeoglobus fulgidus DSM 4304, Archaeoglobus fulgidus VC-16, Archaeoglobus fulgidus str. DSM 4304, Archaeoglobus fulgidus strain DSM 4304
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