AF_2237 protein (Archaeoglobus fulgidus) - STRING interaction network

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AF_2237

HAM1 protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides xanthosine triphosphate (XTP), deoxyinosine triphosphate (dITP) and ITP. Probably functions as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Shows very low activity on dGTP or dUTP, and has nearly no activity toward the canonical nucleotides ATP, CTP, and TTP; Belongs to [...] (181 aa)

Predicted Functional Partners:

guaAB

0.955

ndk

0.955

guaAA

0.946

surE

0.912

rps3ae

0.774

rrp41

0.766

AF_1414

0.761

purA

0.747

AF_0799

0.729

AF_0919

0.729

Your Current Organism:

Archaeoglobus fulgidus

NCBI taxonomy Id: 224325
Other names: A. fulgidus DSM 4304, Archaeoglobus fulgidus DSM 4304, Archaeoglobus fulgidus VC-16, Archaeoglobus fulgidus str. DSM 4304, Archaeoglobus fulgidus strain DSM 4304

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AF_0799	AF_2237	AF_0799	AF_2237	Conserved hypothetical protein; Similar to GB:L77117 SP:Q58040 PID:1591334 percent identity: 42.96; identified by sequence similarity; putative.	HAM1 protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides xanthosine triphosphate (XTP), deoxyinosine triphosphate (dITP) and ITP. Probably functions as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Shows very low activity on dGTP or dUTP, and has nearly no activity toward the canonical nucleotides ATP, CTP, and TTP; Belongs to [...]	0.729
AF_0919	AF_2237	AF_0919	AF_2237	Conserved hypothetical protein; Similar to GB:L77117 SP:Q58346 PID:1499771 percent identity: 40.97; identified by sequence similarity; putative.	HAM1 protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides xanthosine triphosphate (XTP), deoxyinosine triphosphate (dITP) and ITP. Probably functions as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Shows very low activity on dGTP or dUTP, and has nearly no activity toward the canonical nucleotides ATP, CTP, and TTP; Belongs to [...]	0.729
AF_1414	AF_2237	AF_1414	AF_2237	Dihydropteroate synthase; Similar to GB:L77117 SP:Q57571 PID:1590884 percent identity: 40.82; identified by sequence similarity; putative.	HAM1 protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides xanthosine triphosphate (XTP), deoxyinosine triphosphate (dITP) and ITP. Probably functions as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Shows very low activity on dGTP or dUTP, and has nearly no activity toward the canonical nucleotides ATP, CTP, and TTP; Belongs to [...]	0.761
AF_1414	ndk	AF_1414	AF_0767	Dihydropteroate synthase; Similar to GB:L77117 SP:Q57571 PID:1590884 percent identity: 40.82; identified by sequence similarity; putative.	Nucleoside diphosphate kinase (ndk); Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.	0.498
AF_1414	purA	AF_1414	AF_0841	Dihydropteroate synthase; Similar to GB:L77117 SP:Q57571 PID:1590884 percent identity: 40.82; identified by sequence similarity; putative.	Adenylosuccinate synthetase (purA); Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.	0.463
AF_2237	AF_0799	AF_2237	AF_0799	HAM1 protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides xanthosine triphosphate (XTP), deoxyinosine triphosphate (dITP) and ITP. Probably functions as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Shows very low activity on dGTP or dUTP, and has nearly no activity toward the canonical nucleotides ATP, CTP, and TTP; Belongs to [...]	Conserved hypothetical protein; Similar to GB:L77117 SP:Q58040 PID:1591334 percent identity: 42.96; identified by sequence similarity; putative.	0.729
AF_2237	AF_0919	AF_2237	AF_0919	HAM1 protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides xanthosine triphosphate (XTP), deoxyinosine triphosphate (dITP) and ITP. Probably functions as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Shows very low activity on dGTP or dUTP, and has nearly no activity toward the canonical nucleotides ATP, CTP, and TTP; Belongs to [...]	Conserved hypothetical protein; Similar to GB:L77117 SP:Q58346 PID:1499771 percent identity: 40.97; identified by sequence similarity; putative.	0.729
AF_2237	AF_1414	AF_2237	AF_1414	HAM1 protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides xanthosine triphosphate (XTP), deoxyinosine triphosphate (dITP) and ITP. Probably functions as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Shows very low activity on dGTP or dUTP, and has nearly no activity toward the canonical nucleotides ATP, CTP, and TTP; Belongs to [...]	Dihydropteroate synthase; Similar to GB:L77117 SP:Q57571 PID:1590884 percent identity: 40.82; identified by sequence similarity; putative.	0.761
AF_2237	guaAA	AF_2237	AF_1320	HAM1 protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides xanthosine triphosphate (XTP), deoxyinosine triphosphate (dITP) and ITP. Probably functions as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Shows very low activity on dGTP or dUTP, and has nearly no activity toward the canonical nucleotides ATP, CTP, and TTP; Belongs to [...]	GMP synthase (guaA-2); Catalyzes the synthesis of GMP from XMP.	0.946
AF_2237	guaAB	AF_2237	AF_0253	HAM1 protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides xanthosine triphosphate (XTP), deoxyinosine triphosphate (dITP) and ITP. Probably functions as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Shows very low activity on dGTP or dUTP, and has nearly no activity toward the canonical nucleotides ATP, CTP, and TTP; Belongs to [...]	GMP synthase (guaA-1); Catalyzes the synthesis of GMP from XMP.	0.955
AF_2237	ndk	AF_2237	AF_0767	HAM1 protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides xanthosine triphosphate (XTP), deoxyinosine triphosphate (dITP) and ITP. Probably functions as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Shows very low activity on dGTP or dUTP, and has nearly no activity toward the canonical nucleotides ATP, CTP, and TTP; Belongs to [...]	Nucleoside diphosphate kinase (ndk); Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.	0.955
AF_2237	purA	AF_2237	AF_0841	HAM1 protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides xanthosine triphosphate (XTP), deoxyinosine triphosphate (dITP) and ITP. Probably functions as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Shows very low activity on dGTP or dUTP, and has nearly no activity toward the canonical nucleotides ATP, CTP, and TTP; Belongs to [...]	Adenylosuccinate synthetase (purA); Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.	0.747
AF_2237	rps3ae	AF_2237	AF_2320	HAM1 protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides xanthosine triphosphate (XTP), deoxyinosine triphosphate (dITP) and ITP. Probably functions as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Shows very low activity on dGTP or dUTP, and has nearly no activity toward the canonical nucleotides ATP, CTP, and TTP; Belongs to [...]	SSU ribosomal protein S3AE (rps3AE); Similar to GB:L77117 SP:P54059 PID:1499819 percent identity: 39.42; identified by sequence similarity; putative; Belongs to the eukaryotic ribosomal protein eS1 family.	0.774
AF_2237	rrp41	AF_2237	AF_0493	HAM1 protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides xanthosine triphosphate (XTP), deoxyinosine triphosphate (dITP) and ITP. Probably functions as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Shows very low activity on dGTP or dUTP, and has nearly no activity toward the canonical nucleotides ATP, CTP, and TTP; Belongs to [...]	Ribonuclease PH (rph); Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'->5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails (Probable).	0.766
AF_2237	surE	AF_2237	AF_0942	HAM1 protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides xanthosine triphosphate (XTP), deoxyinosine triphosphate (dITP) and ITP. Probably functions as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Shows very low activity on dGTP or dUTP, and has nearly no activity toward the canonical nucleotides ATP, CTP, and TTP; Belongs to [...]	surE stationary-phase survival protein (surE); Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.	0.912
guaAA	AF_2237	AF_1320	AF_2237	GMP synthase (guaA-2); Catalyzes the synthesis of GMP from XMP.	HAM1 protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides xanthosine triphosphate (XTP), deoxyinosine triphosphate (dITP) and ITP. Probably functions as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Shows very low activity on dGTP or dUTP, and has nearly no activity toward the canonical nucleotides ATP, CTP, and TTP; Belongs to [...]	0.946
guaAA	guaAB	AF_1320	AF_0253	GMP synthase (guaA-2); Catalyzes the synthesis of GMP from XMP.	GMP synthase (guaA-1); Catalyzes the synthesis of GMP from XMP.	0.998
guaAA	purA	AF_1320	AF_0841	GMP synthase (guaA-2); Catalyzes the synthesis of GMP from XMP.	Adenylosuccinate synthetase (purA); Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.	0.828
guaAA	surE	AF_1320	AF_0942	GMP synthase (guaA-2); Catalyzes the synthesis of GMP from XMP.	surE stationary-phase survival protein (surE); Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.	0.927
guaAB	AF_2237	AF_0253	AF_2237	GMP synthase (guaA-1); Catalyzes the synthesis of GMP from XMP.	HAM1 protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides xanthosine triphosphate (XTP), deoxyinosine triphosphate (dITP) and ITP. Probably functions as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Shows very low activity on dGTP or dUTP, and has nearly no activity toward the canonical nucleotides ATP, CTP, and TTP; Belongs to [...]	0.955

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