Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
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thsAThermosome, subunit alpha (thsA); Molecular chaperone; binds unfolded polypeptides in vitro, and has a weak ATPase activity; Belongs to the TCP-1 chaperonin family. (545 aa)    
Predicted Functional Partners:
AF_0364
ATP-dependent protease La (lon); ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Degrades polypeptides processively (By similarity).
  
 
 0.912
AF_1971
Small heat shock protein (hsp20-2); Similar to SP:P19244 percent identity: 38.14; identified by sequence similarity; putative; Belongs to the small heat shock protein (HSP20) family.
  
  
 0.893
mdh
L-malate dehydrogenase, NAD+-dependent (mdhA); Catalyzes the reversible oxidation of malate to oxaloacetate. Can also oxidize tartrate.
  
 0.883
AF_1297
Cell division control protein 48, AAA family (cdc48-1); Similar to GB:L77117 SP:Q58556 PID:1591785 percent identity: 69.10; identified by sequence similarity; putative; Belongs to the AAA ATPase family. CDC48 subfamily.
  
 0.876
fusA
Translation elongation factor EF-2 (fus); Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity); Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor G [...]
 
 
 0.856
AF_1296
Small heat shock protein (hsp20-1); Similar to GB:L77117 SP:Q57733 PID:1591008 percent identity: 52.27; identified by sequence similarity; putative; Belongs to the small heat shock protein (HSP20) family.
  
  
 0.855
rps2
SSU ribosomal protein S2P (rps2P); Similar to GB:L77117 SP:P54109 PID:1591644 percent identity: 58.33; identified by sequence similarity; putative; Belongs to the universal ribosomal protein uS2 family.
 
 0.850
pfdB
erpK protein, putative; Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding (By similarity).
  
 0.841
AF_1318
Predicted coding region AF_1318; Might play a role in defense against invading genetic elements, using short DNA sequences as guides to bind complementary target strands, resulting in slicing of the target nucleic acid (By similarity). Binds nucleic acids with decreasing affinity in the following order; ssDNA, ssRNA, dsDNA, RNA-DNA, RNA-RNA. Association of the 5' seed region of the guide strand (nucleotides 2-7) with AfPiwi increases affinity for the corresponding target strand; the greatest increase in affinity is for guide DNA with target RNA.
      
 0.820
tbp
Transcription initiation factor IID; General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation (By similarity).
 
 
 0.818
Your Current Organism:
Archaeoglobus fulgidus
NCBI taxonomy Id: 224325
Other names: A. fulgidus DSM 4304, Archaeoglobus fulgidus DSM 4304, Archaeoglobus fulgidus VC-16, Archaeoglobus fulgidus str. DSM 4304, Archaeoglobus fulgidus strain DSM 4304
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