Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
mvkMevalonate kinase (mvk); Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)- mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids; Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (284 aa)    
Predicted Functional Partners:
hmgA
3-hydroxy-3-methylglutaryl-coenzyme A reductase (mvaA); Converts HMG-CoA to mevalonate.
 0.999
fni
Carotenoid biosynthetic gene ERWCRTS, putative; Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
 
  
 0.989
AF_2288
Acetylglutamate kinase, putative; Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids.
 
   
 0.963
AF_2286
Geranylgeranyl diphosphate synthase, type I; Similar to PID:913252 SP:Q53479 percent identity: 42.68; identified by sequence similarity; putative; Belongs to the FPP/GGPP synthase family.
 
  
 0.936
AF_2333
Conserved hypothetical protein; Similar to GB:L77117 PID:1591952 percent identity: 45.50; identified by sequence similarity; putative.
    
  0.913
AF_0055
Conserved hypothetical protein; Similar to GB:L77117 PID:1592056 percent identity: 48.00; identified by sequence similarity; putative; Belongs to the UPF0107 family.
    
  0.902
rnz
Conserved hypothetical protein; Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA; Belongs to the RNase Z family.
  
   
 0.834
tpiA
Triosephosphate isomerase (tpiA); Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family.
  
   
 0.822
eif2g
Translation initiation factor eIF-2, subunit gamma (eif2G); eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.
  
  
 0.817
sepS
Conserved hypothetical protein; Catalyzes the attachment of O-phosphoserine (Sep) to tRNA(Cys); Belongs to the class-II aminoacyl-tRNA synthetase family. O-phosphoseryl-tRNA(Cys) synthetase subfamily.
   
 
 0.804
Your Current Organism:
Archaeoglobus fulgidus
NCBI taxonomy Id: 224325
Other names: A. fulgidus DSM 4304, Archaeoglobus fulgidus DSM 4304, Archaeoglobus fulgidus VC-16, Archaeoglobus fulgidus str. DSM 4304, Archaeoglobus fulgidus strain DSM 4304
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