close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AF_2335Conserved hypothetical protein; Similar to GP:1200033 percent identity: 39.64; identified by sequence similarity; putative. (170 aa)    
Predicted Functional Partners:
thiM
Hydroxyethylthiazole kinase (thiM); Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family.
    
 0.877
thiE
Thiamine phosphate pyrophosphorylase (thiE); Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.
      0.872
speE
Spermidine synthase (speE); Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
       0.594
AF_2333
Conserved hypothetical protein; Similar to GB:L77117 PID:1591952 percent identity: 45.50; identified by sequence similarity; putative.
       0.565
trpCD
Anthranilate synthase component II (trpD); Bifunctional enzyme that catalyzes the second and fourth steps of tryptophan biosynthetic pathway. The second step is catalyzed by the anthranilate phosphoribosyltransferase, coded by the TrpD domain and the fourth step is catalyzed by indole-3-glycerol phosphate synthase, coded by the TrpC domain (By similarity).
     
 0.564
gpsA
Glycerol-3-phosphate dehydrogenase (NAD(P)+) (gpsA); Similar to SP:P46919 PID:974332 PID:1146220 GB:AL009126 percent identity: 36.31; identified by sequence similarity; putative.
  
 
 0.548
AF_0345
Predicted coding region AF_0345; Hypothetical protein; identified by GeneMark; putative.
  
    0.458
AF_1207
2-deoxy-D-gluconate 3-dehydrogenase (kduD); Similar to SP:Q05528 GB:X62073 PID:48986 percent identity: 45.31; identified by sequence similarity; putative.
  
 
 0.414
cbiHC
Cobalamin biosynthesis precorrin-3 methylase (cbiH); Bifunctional enzyme with a methyltransferase domain that catalyzes the ring contraction and methylation of C-17 in cobalt-factor III to form cobalt-factor IV, and an isomerase domain that catalyzes the conversion of cobalt-precorrin-8 to cobyrinate; In the C-terminal section; belongs to the CobH family.
     
 0.411
nadC
Nicotinate-nucleotide pyrophosphorylase (nadC); Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family.
  
 
 0.406
Your Current Organism:
Archaeoglobus fulgidus
NCBI taxonomy Id: 224325
Other names: A. fulgidus DSM 4304, Archaeoglobus fulgidus DSM 4304, Archaeoglobus fulgidus VC-16, Archaeoglobus fulgidus str. DSM 4304, Archaeoglobus fulgidus strain DSM 4304
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.