| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AF_1488 | AF_2315 | AF_1488 | AF_2315 | Conserved hypothetical protein; Similar to GB:L77117 SP:Q57961 PID:1591245 percent identity: 44.64; identified by sequence similarity; putative; Belongs to the archaeal NMN adenylyltransferase family. | Conserved hypothetical protein; Similar to GP:1591245 percent identity: 57.40; identified by sequence similarity; putative. | 0.905 |
| AF_1488 | cobB1 | AF_1488 | AF_1676 | Conserved hypothetical protein; Similar to GB:L77117 SP:Q57961 PID:1591245 percent identity: 44.64; identified by sequence similarity; putative; Belongs to the archaeal NMN adenylyltransferase family. | Transcriptional regulatory protein, Sir2 family; NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription. | 0.955 |
| AF_1488 | cobB2 | AF_1488 | AF_0112 | Conserved hypothetical protein; Similar to GB:L77117 SP:Q57961 PID:1591245 percent identity: 44.64; identified by sequence similarity; putative; Belongs to the archaeal NMN adenylyltransferase family. | Transcriptional regulatory protein, Sir2 family; NAD-dependent protein deacetylase which modulates the activities of several proteins which are inactive in their acetylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription. | 0.955 |
| AF_1488 | nadE | AF_1488 | AF_1000 | Conserved hypothetical protein; Similar to GB:L77117 SP:Q57961 PID:1591245 percent identity: 44.64; identified by sequence similarity; putative; Belongs to the archaeal NMN adenylyltransferase family. | NH(3)-dependent NAD+ synthetase (nadE); Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. | 0.945 |
| AF_1488 | nadK | AF_1488 | AF_2373 | Conserved hypothetical protein; Similar to GB:L77117 SP:Q57961 PID:1591245 percent identity: 44.64; identified by sequence similarity; putative; Belongs to the archaeal NMN adenylyltransferase family. | Conserved hypothetical protein; Involved in the regulation of the intracellular balance between NAD(H) and NADP(H), and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.916 |
| AF_2184 | nadK | AF_2184 | AF_2373 | Conserved hypothetical protein; Similar to PID:1653500 percent identity: 33.33; identified by sequence similarity; putative. | Conserved hypothetical protein; Involved in the regulation of the intracellular balance between NAD(H) and NADP(H), and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.615 |
| AF_2184 | srp54 | AF_2184 | AF_0622 | Conserved hypothetical protein; Similar to PID:1653500 percent identity: 33.33; identified by sequence similarity; putative. | Signal recognition particle, subunit SRP54 (srp54); Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY (Probable). Belongs to the GTP-binding SRP family. SRP54 subfamily. | 0.510 |
| AF_2315 | AF_1488 | AF_2315 | AF_1488 | Conserved hypothetical protein; Similar to GP:1591245 percent identity: 57.40; identified by sequence similarity; putative. | Conserved hypothetical protein; Similar to GB:L77117 SP:Q57961 PID:1591245 percent identity: 44.64; identified by sequence similarity; putative; Belongs to the archaeal NMN adenylyltransferase family. | 0.905 |
| AF_2315 | cobB1 | AF_2315 | AF_1676 | Conserved hypothetical protein; Similar to GP:1591245 percent identity: 57.40; identified by sequence similarity; putative. | Transcriptional regulatory protein, Sir2 family; NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription. | 0.955 |
| AF_2315 | cobB2 | AF_2315 | AF_0112 | Conserved hypothetical protein; Similar to GP:1591245 percent identity: 57.40; identified by sequence similarity; putative. | Transcriptional regulatory protein, Sir2 family; NAD-dependent protein deacetylase which modulates the activities of several proteins which are inactive in their acetylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription. | 0.955 |
| AF_2315 | nadE | AF_2315 | AF_1000 | Conserved hypothetical protein; Similar to GP:1591245 percent identity: 57.40; identified by sequence similarity; putative. | NH(3)-dependent NAD+ synthetase (nadE); Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. | 0.943 |
| AF_2315 | nadK | AF_2315 | AF_2373 | Conserved hypothetical protein; Similar to GP:1591245 percent identity: 57.40; identified by sequence similarity; putative. | Conserved hypothetical protein; Involved in the regulation of the intracellular balance between NAD(H) and NADP(H), and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.916 |
| AF_2371 | nadK | AF_2371 | AF_2373 | Predicted coding region AF_2371; Hypothetical protein; identified by GeneMark; putative. | Conserved hypothetical protein; Involved in the regulation of the intracellular balance between NAD(H) and NADP(H), and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.741 |
| AF_2371 | suhB | AF_2371 | AF_2372 | Predicted coding region AF_2371; Hypothetical protein; identified by GeneMark; putative. | Extragenic suppressor (suhB); Phosphatase with broad specificity; it can dephosphorylate fructose 1,6-bisphosphate, both D and L isomers of inositol-1-phosphate (I-1-P), 2'-AMP, pNPP, inositol-2-phosphate, beta-glycerol phosphate, and alpha-D-glucose-1-phosphate. Cannot hydrolyze glucose-6-phosphate and fructose-6-phosphate. May be involved in the biosynthesis of a unique osmolyte, di-myo-inositol 1,1-phosphate. | 0.741 |
| aroE | nadK | AF_2327 | AF_2373 | Shikimate 5-dehydrogenase (aroE); Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). | Conserved hypothetical protein; Involved in the regulation of the intracellular balance between NAD(H) and NADP(H), and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.641 |
| aroE | suhB | AF_2327 | AF_2372 | Shikimate 5-dehydrogenase (aroE); Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). | Extragenic suppressor (suhB); Phosphatase with broad specificity; it can dephosphorylate fructose 1,6-bisphosphate, both D and L isomers of inositol-1-phosphate (I-1-P), 2'-AMP, pNPP, inositol-2-phosphate, beta-glycerol phosphate, and alpha-D-glucose-1-phosphate. Cannot hydrolyze glucose-6-phosphate and fructose-6-phosphate. May be involved in the biosynthesis of a unique osmolyte, di-myo-inositol 1,1-phosphate. | 0.594 |
| cobB1 | AF_1488 | AF_1676 | AF_1488 | Transcriptional regulatory protein, Sir2 family; NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription. | Conserved hypothetical protein; Similar to GB:L77117 SP:Q57961 PID:1591245 percent identity: 44.64; identified by sequence similarity; putative; Belongs to the archaeal NMN adenylyltransferase family. | 0.955 |
| cobB1 | AF_2315 | AF_1676 | AF_2315 | Transcriptional regulatory protein, Sir2 family; NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription. | Conserved hypothetical protein; Similar to GP:1591245 percent identity: 57.40; identified by sequence similarity; putative. | 0.955 |
| cobB1 | cobB2 | AF_1676 | AF_0112 | Transcriptional regulatory protein, Sir2 family; NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription. | Transcriptional regulatory protein, Sir2 family; NAD-dependent protein deacetylase which modulates the activities of several proteins which are inactive in their acetylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription. | 0.910 |
| cobB1 | nadE | AF_1676 | AF_1000 | Transcriptional regulatory protein, Sir2 family; NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription. | NH(3)-dependent NAD+ synthetase (nadE); Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. | 0.929 |
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