Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
AF_2420Signal-transducing histidine kinase, putative; Similar to PID:1652132 percent identity: 28.36; identified by sequence similarity; putative. (547 aa)    
Predicted Functional Partners:
AF_2419
Response regulator; Similar to PID:1086465 percent identity: 37.93; identified by sequence similarity; putative.
   
 
 0.824
AF_2418
DNA repair protein, putative; Similar to GB:U64315 SP:Q92889 PID:1524411 PID:1905924 percent identity: 28.86; identified by sequence similarity; putative.
  
    0.775
leuS
leucyl-tRNA synthetase (leuS); Similar to GB:L77117 SP:Q58050 PID:1591345 percent identity: 49.68; identified by sequence similarity; putative; Belongs to the class-I aminoacyl-tRNA synthetase family.
  
 
 0.666
AF_1045
Methyl-accepting chemotaxis protein (tlpC-2); Similar to GB:Z34005 SP:P39209 GB:D30762 PID:496484 PID:710635 percent identity: 29.58; identified by sequence similarity; putative.
 
  
 0.662
AF_2429
enoyl-CoA hydratase (fad-5); Similar to GB:U00010 PID:466794 SP:P53526 percent identity: 34.67; identified by sequence similarity; putative.
  
 0.596
prs2
Ribose-phosphate pyrophosphokinase (prsA-2); Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P).
 
 
 0.594
AF_0364
ATP-dependent protease La (lon); ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Degrades polypeptides processively (By similarity).
 
 
 0.552
prs1
Ribose-phosphate pyrophosphokinase (prsA-1); Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P).
   
 0.538
AF_2220
Predicted coding region AF_2220; Hypothetical protein; identified by GeneMark; putative.
   
 0.525
AF_0893
Signal-transducing histidine kinase; Similar to PID:1001492 PID:1001594 percent identity: 28.74; identified by sequence similarity; putative.
 
   
 0.521
Your Current Organism:
Archaeoglobus fulgidus
NCBI taxonomy Id: 224325
Other names: A. fulgidus DSM 4304, Archaeoglobus fulgidus DSM 4304, Archaeoglobus fulgidus VC-16, Archaeoglobus fulgidus str. DSM 4304, Archaeoglobus fulgidus strain DSM 4304
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