STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hoxAChemotaxis protein CheY; Probable member of the two-component regulatory system involved in the regulation of the hydrogenase activity. HoxA is probably phosphorylated by a sensory component (which could be HoxX) and then acts in conjunction with sigma-54 as a transcriptional activator. (485 aa)    
Predicted Functional Partners:
AND91922.1
Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 0.994
hupK
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the HupK family.
 
   
 0.855
hypC
Hydrogenase assembly protein HupF; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
   0.818
hypB
Hydrogenase nickel incorporation protein HypB; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. Exhibits a low intrinsic GTPase activity, which is essential for nickel insertion.
  
  
 0.814
hypD2
Hydrogenase formation protein HupD; Involved in the maturation of [NiFe] hydrogenases. Involved in the biosynthesis of the Fe(CN)(2)CO cofactor.
  
  
 0.807
hypE-2
Hydrogenase; Involved in the maturation of [NiFe] hydrogenases. Along with HypF, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypE catalyzes the ATP-dependent dehydration of the carboxamido group attached to its C-terminal cysteine to a cyano group.
  
    0.801
hupJ
Hydrogenase formation protein HupJ; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the HupJ family.
 
   
 0.801
hupG
Hydrogenase accessory protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the HupG/HyaE family.
 
  
 0.799
hypF-2
Carbamoyltransferase; Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide.
  
    0.783
hypA2
Hydrogenase nickel incorporation protein HypA; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.
       0.783
Your Current Organism:
Bradyrhizobium diazoefficiens
NCBI taxonomy Id: 224911
Other names: B. diazoefficiens USDA 110, Bradyrhizobium diazoefficiens USDA 110, Bradyrhizobium japonicum USDA 110
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