STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hisIphosphoribosyl-AMP cyclohydrolase; COG0139; COG0140; histidine biosynthesis bifunctional protein HisIE; PRA-CH; PRA-PH; In the C-terminal section; belongs to the PRA-PH family. (206 aa)    
Predicted Functional Partners:
hisG
ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
 
 
 0.999
hisD
Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine.
 
  
 0.999
hisC
Histidinol-phosphate aminotransferase; COG0079; imidazole; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
 
  
 0.999
hisB
Histidinol-phosphatase; COG0241; COG0131; histidine biosynthesis bifunctional protein HisB; IGPD; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family.
 
  
 0.999
hisH
Amidotransferase HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.
 
  
 0.999
hisA
Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; COG0106.
 
 0.999
hisF
HisF protein; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
  
 0.999
yfhC
Putative deaminase; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family.
   
  
 0.987
thrA
Aspartokinase; COG0527; COG0460; bifunctional aspartokinase/homoserine dehydrogenase (AK-HD); In the C-terminal section; belongs to the homoserine dehydrogenase family.
  
  
 0.928
rpmE
50S ribosomal protein L31; Binds the 23S rRNA.
  
  
 0.927
Your Current Organism:
Buchnera aphidicola Bp
NCBI taxonomy Id: 224915
Other names: B. aphidicola str. Bp (Baizongia pistaciae), Buchnera aphidicola (subsp. Baizongia pistaciae), Buchnera aphidicola str. Bp (Baizongia pistaciae)
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