node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SJZ39990.1 | SJZ42730.1 | SAMN02745152_00086 | SAMN02745152_00193 | XTP/dITP diphosphohydrolase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Manganese-dependent inorganic pyrophosphatase. | 0.539 |
SJZ39990.1 | SJZ67479.1 | SAMN02745152_00086 | SAMN02745152_00896 | XTP/dITP diphosphohydrolase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | IMP dehydrogenase. | 0.896 |
SJZ39990.1 | SJZ82085.1 | SAMN02745152_00086 | SAMN02745152_01302 | XTP/dITP diphosphohydrolase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | GMP synthase (glutamine-hydrolysing). | 0.962 |
SJZ39990.1 | SJZ91189.1 | SAMN02745152_00086 | SAMN02745152_01601 | XTP/dITP diphosphohydrolase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Acetoin utilization protein AcuB. | 0.589 |
SJZ39990.1 | SKA06140.1 | SAMN02745152_00086 | SAMN02745152_02079 | XTP/dITP diphosphohydrolase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Glutamate synthase (ferredoxin). | 0.612 |
SJZ39990.1 | apt | SAMN02745152_00086 | SAMN02745152_00525 | XTP/dITP diphosphohydrolase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.610 |
SJZ39990.1 | purA | SAMN02745152_00086 | SAMN02745152_01665 | XTP/dITP diphosphohydrolase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.791 |
SJZ42730.1 | SJZ39990.1 | SAMN02745152_00193 | SAMN02745152_00086 | Manganese-dependent inorganic pyrophosphatase. | XTP/dITP diphosphohydrolase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.539 |
SJZ42730.1 | SJZ67479.1 | SAMN02745152_00193 | SAMN02745152_00896 | Manganese-dependent inorganic pyrophosphatase. | IMP dehydrogenase. | 0.948 |
SJZ42730.1 | SJZ82085.1 | SAMN02745152_00193 | SAMN02745152_01302 | Manganese-dependent inorganic pyrophosphatase. | GMP synthase (glutamine-hydrolysing). | 0.981 |
SJZ42730.1 | SJZ82416.1 | SAMN02745152_00193 | SAMN02745152_01317 | Manganese-dependent inorganic pyrophosphatase. | 5-methyltetrahydrofolate--homocysteine methyltransferase. | 0.897 |
SJZ42730.1 | SJZ91153.1 | SAMN02745152_00193 | SAMN02745152_01599 | Manganese-dependent inorganic pyrophosphatase. | Branched-chain amino acid transport system ATP-binding protein. | 0.440 |
SJZ42730.1 | SJZ91189.1 | SAMN02745152_00193 | SAMN02745152_01601 | Manganese-dependent inorganic pyrophosphatase. | Acetoin utilization protein AcuB. | 0.844 |
SJZ42730.1 | SKA06140.1 | SAMN02745152_00193 | SAMN02745152_02079 | Manganese-dependent inorganic pyrophosphatase. | Glutamate synthase (ferredoxin). | 0.765 |
SJZ42730.1 | apt | SAMN02745152_00193 | SAMN02745152_00525 | Manganese-dependent inorganic pyrophosphatase. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.705 |
SJZ42730.1 | purA | SAMN02745152_00193 | SAMN02745152_01665 | Manganese-dependent inorganic pyrophosphatase. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.706 |
SJZ67479.1 | SJZ39990.1 | SAMN02745152_00896 | SAMN02745152_00086 | IMP dehydrogenase. | XTP/dITP diphosphohydrolase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.896 |
SJZ67479.1 | SJZ42730.1 | SAMN02745152_00896 | SAMN02745152_00193 | IMP dehydrogenase. | Manganese-dependent inorganic pyrophosphatase. | 0.948 |
SJZ67479.1 | SJZ82085.1 | SAMN02745152_00896 | SAMN02745152_01302 | IMP dehydrogenase. | GMP synthase (glutamine-hydrolysing). | 0.998 |
SJZ67479.1 | SJZ91189.1 | SAMN02745152_00896 | SAMN02745152_01601 | IMP dehydrogenase. | Acetoin utilization protein AcuB. | 0.809 |