STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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SKA04289.1Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (492 aa)    
Predicted Functional Partners:
SJZ42621.1
Acetolactate synthase, small subunit.
  
 
 0.993
SJZ42276.1
Acetolactate synthase, large subunit.
 
 
 0.976
ilvD
Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family.
  
 
 0.975
SJZ52675.1
Acetolactate synthase, large subunit.
 
 
 0.974
SJZ43948.1
3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit; Belongs to the aconitase/IPM isomerase family.
 
  
 0.918
SJZ43930.1
3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit; Belongs to the LeuD family.
 
  
 0.899
leuB
3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
  
  
 0.854
SJZ66793.1
Phosphonopyruvate decarboxylase.
  
 
 0.837
SJZ56186.1
Aspartate kinase.
 
  
 0.805
SKA06140.1
Glutamate synthase (ferredoxin).
  
  
 0.791
Your Current Organism:
Treponema berlinense
NCBI taxonomy Id: 225004
Other names: ATCC BAA-909, CIP 108244, JCM 12341, T. berlinense, Treponema berlinense Nordhoff et al. 2005, Treponema sp. 7CPL208, strain 7CPL208
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