STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
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[Homology]
Score
V4BRP6_LOTGIStructure-specific endonuclease subunit SLX1 homolog; Catalytic subunit of a heterodimeric structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA; Belongs to the SLX1 family. (257 aa)    
Predicted Functional Partners:
V3ZZV8_LOTGI
ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.
    
 0.968
V4A380_LOTGI
3'-5' exonuclease domain-containing protein.
    
 0.968
V4AAI8_LOTGI
BTB domain-containing protein.
   
 0.955
V3ZYD5_LOTGI
Uncharacterized protein.
   
 0.946
V4BFG0_LOTGI
ERCC4 domain-containing protein.
   
 0.946
V4AZ14_LOTGI
AA_TRNA_LIGASE_II domain-containing protein.
   
 0.932
V4BK15_LOTGI
Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family.
    
 
 0.910
V4C7S3_LOTGI
ERCC4 domain-containing protein.
   
 0.865
V4C4L0_LOTGI
ERCC4 domain-containing protein.
   
 0.858
V3Z9S6_LOTGI
Uncharacterized protein.
     
 0.844
Your Current Organism:
Lottia gigantea
NCBI taxonomy Id: 225164
Other names: L. gigantea, owl limpet
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.