SKA24377.1 protein (Enhydrobacter aerosaccus)

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second shell of interactors

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Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Score

SKA24377.1

CreA protein. (151 aa)

Predicted Functional Partners:

SKA20686.1

0.530

SKA31074.1

0.515

SKA02365.1

0.510

SJZ41445.1

0.503

SJZ46130.1

0.503

SJZ53500.1

0.500

SKA24388.1

0.460

SJZ59589.1

0.445

SJZ91952.1

0.443

SKA31063.1

0.433

Your Current Organism:

Enhydrobacter aerosaccus

NCBI taxonomy Id: 225324
Other names: ATCC 27094, CCUG 58314, DSM 8914, E. aerosaccus, NCIMB 12535

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SJZ41445.1	SKA24377.1	SAMN02745126_00952	SAMN02745126_04398	Molecular chaperone IbpA; Belongs to the small heat shock protein (HSP20) family.	CreA protein.	0.503
SJZ46130.1	SKA24377.1	SAMN02745126_01167	SAMN02745126_04398	Exo-beta-1,3-glucanase, GH17 family.	CreA protein.	0.503
SJZ53500.1	SKA02365.1	SAMN02745126_01528	SAMN02745126_03189	Penicillin-insensitive murein endopeptidase.	Uncharacterized conserved protein YcbK, DUF882 family.	0.761
SJZ53500.1	SKA24377.1	SAMN02745126_01528	SAMN02745126_04398	Penicillin-insensitive murein endopeptidase.	CreA protein.	0.500
SJZ59589.1	SKA24377.1	SAMN02745126_01775	SAMN02745126_04398	Molecular chaperone IbpA; Belongs to the small heat shock protein (HSP20) family.	CreA protein.	0.445
SJZ91952.1	SKA24377.1	SAMN02745126_02872	SAMN02745126_04398	Molecular chaperone IbpA, HSP20 family; Belongs to the small heat shock protein (HSP20) family.	CreA protein.	0.443
SJZ91952.1	SKA31074.1	SAMN02745126_02872	SAMN02745126_05083	Molecular chaperone IbpA, HSP20 family; Belongs to the small heat shock protein (HSP20) family.	Paraquat-inducible protein A.	0.465
SKA02365.1	SJZ53500.1	SAMN02745126_03189	SAMN02745126_01528	Uncharacterized conserved protein YcbK, DUF882 family.	Penicillin-insensitive murein endopeptidase.	0.761
SKA02365.1	SKA20686.1	SAMN02745126_03189	SAMN02745126_04133	Uncharacterized conserved protein YcbK, DUF882 family.	Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase.	0.456
SKA02365.1	SKA24377.1	SAMN02745126_03189	SAMN02745126_04398	Uncharacterized conserved protein YcbK, DUF882 family.	CreA protein.	0.510
SKA20686.1	SKA02365.1	SAMN02745126_04133	SAMN02745126_03189	Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase.	Uncharacterized conserved protein YcbK, DUF882 family.	0.456
SKA20686.1	SKA24377.1	SAMN02745126_04133	SAMN02745126_04398	Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase.	CreA protein.	0.530
SKA24377.1	SJZ41445.1	SAMN02745126_04398	SAMN02745126_00952	CreA protein.	Molecular chaperone IbpA; Belongs to the small heat shock protein (HSP20) family.	0.503
SKA24377.1	SJZ46130.1	SAMN02745126_04398	SAMN02745126_01167	CreA protein.	Exo-beta-1,3-glucanase, GH17 family.	0.503
SKA24377.1	SJZ53500.1	SAMN02745126_04398	SAMN02745126_01528	CreA protein.	Penicillin-insensitive murein endopeptidase.	0.500
SKA24377.1	SJZ59589.1	SAMN02745126_04398	SAMN02745126_01775	CreA protein.	Molecular chaperone IbpA; Belongs to the small heat shock protein (HSP20) family.	0.445
SKA24377.1	SJZ91952.1	SAMN02745126_04398	SAMN02745126_02872	CreA protein.	Molecular chaperone IbpA, HSP20 family; Belongs to the small heat shock protein (HSP20) family.	0.443
SKA24377.1	SKA02365.1	SAMN02745126_04398	SAMN02745126_03189	CreA protein.	Uncharacterized conserved protein YcbK, DUF882 family.	0.510
SKA24377.1	SKA20686.1	SAMN02745126_04398	SAMN02745126_04133	CreA protein.	Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase.	0.530
SKA24377.1	SKA24388.1	SAMN02745126_04398	SAMN02745126_04399	CreA protein.	Hypothetical protein.	0.460

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Network Stats

number of nodes:

11

number of edges:

41

average node degree:

7.45

avg. local clustering coefficient:

0.877

expected number of edges:

21

PPI enrichment p-value:

7.17e-05

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006633

Fatty acid biosynthetic process

7 of 19

2.08

4.33

1.57e-10

GO:2001295

malonyl-CoA biosynthetic process

2 of 5

2.12

1.02

0.0124

GO:0006814

Sodium ion transport

2 of 7

1.97

0.92

0.0180

GO:0044249

Cellular biosynthetic process

9 of 667

0.65

0.52

0.00085

GO:1901576

Organic substance biosynthetic process

9 of 706

0.62

0.49

0.0013

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004312

Fatty acid synthase activity

4 of 8

2.22

2.45

1.52e-05

GO:0016747

Acyltransferase activity, transferring groups other than amino-acyl groups

5 of 44

1.57

1.73

5.39e-05

GO:0003989

acetyl-CoA carboxylase activity

2 of 2

2.52

1.13

0.0085

GO:0004315

3-oxoacyl-[acyl-carrier-protein] synthase activity

2 of 3

2.34

1.06

0.0113

GO:0016743

Carboxyl- or carbamoyltransferase activity

2 of 5

2.12

0.91

0.0198

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009317

acetyl-CoA carboxylase complex

2 of 5

2.12

0.89

0.0219

GO:0005622

Intracellular anatomical structure

10 of 1227

0.43

0.31

0.0219

GO:0005737

Cytoplasm

9 of 1122

0.42

0.29

0.0361

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1452

malonyl-CoA metabolic process, and 3-oxoacyl-[acyl-carrier-protein] synthase activity

7 of 11

2.32

5.37

4.79e-12

CL:1448

Mixed, incl. Fatty acid biosynthetic process, and AMP-binding enzyme C-terminal domain

8 of 32

1.92

4.32

6.31e-12

CL:1454

Fatty acid metabolism, and acetyl-CoA carboxylase activity

5 of 6

2.44

4.17

6.11e-09

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00061

Fatty acid biosynthesis

6 of 15

2.12

4.13

8.47e-10

map01212

Fatty acid metabolism

6 of 21

1.97

3.71

2.29e-09

map00620

Pyruvate metabolism

5 of 70

1.37

1.5

5.01e-05

map01200

Carbon metabolism

5 of 145

1.05

0.88

0.0012

map00780

Biotin metabolism

2 of 14

1.67

0.87

0.0178

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0009317

acetyl-CoA carboxylase complex

4 of 9

2.17

2.53

8.98e-06

GOCC:0005737

Cytoplasm

10 of 855

0.59

0.48

0.00068

GOCC:0005622

Intracellular

11 of 1191

0.48

0.4

0.00068

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0444

Lipid biosynthesis

4 of 17

1.89

2.03

5.00e-05

KW-0012

Acyltransferase

3 of 17

1.76

1.37

0.0014

KW-0275

Fatty acid biosynthesis

2 of 6

2.04

1.08

0.0087

KW-0808

Transferase

6 of 311

0.8

0.57

0.0063

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