purH_2 protein (Clostridium chromiireducens)

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Score

purH_2

Bifunctional purine biosynthesis protein PurH. (501 aa)

Predicted Functional Partners:

purN

0.999

purL

0.998

purF

0.998

purC

0.993

guaB_3

0.987

purD

0.985

purM

0.984

purB

0.983

purE

0.975

glyA

0.972

Your Current Organism:

Clostridium chromiireducens

NCBI taxonomy Id: 225345
Other names: C. chromiireducens, Clostridium chromiireducens Inglett et al. 2011, DSM 23318, KCTC 5935, strain GCAF-1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
glyA	guaB_3	CLCHR_41700	CLCHR_42470	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Inosine-5'-monophosphate dehydrogenase.	0.851
glyA	purB	CLCHR_41700	CLCHR_06560	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.	0.872
glyA	purC	CLCHR_41700	CLCHR_09050	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Phosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family.	0.826
glyA	purD	CLCHR_41700	CLCHR_09100	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Phosphoribosylamine--glycine ligase; Belongs to the GARS family.	0.939
glyA	purE	CLCHR_41700	CLCHR_09040	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	N5-carboxyaminoimidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).	0.495
glyA	purF	CLCHR_41700	CLCHR_09060	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Amidophosphoribosyltransferase precursor; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.	0.867
glyA	purH_2	CLCHR_41700	CLCHR_09090	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Bifunctional purine biosynthesis protein PurH.	0.972
glyA	purL	CLCHR_41700	CLCHR_09030	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Phosphoribosylformylglycinamidine synthase.	0.976
glyA	purM	CLCHR_41700	CLCHR_09070	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Phosphoribosylformylglycinamidine cyclo-ligase.	0.772
glyA	purN	CLCHR_41700	CLCHR_09080	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.	0.961
guaB_3	glyA	CLCHR_42470	CLCHR_41700	Inosine-5'-monophosphate dehydrogenase.	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	0.851
guaB_3	purB	CLCHR_42470	CLCHR_06560	Inosine-5'-monophosphate dehydrogenase.	Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.	0.855
guaB_3	purC	CLCHR_42470	CLCHR_09050	Inosine-5'-monophosphate dehydrogenase.	Phosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family.	0.789
guaB_3	purD	CLCHR_42470	CLCHR_09100	Inosine-5'-monophosphate dehydrogenase.	Phosphoribosylamine--glycine ligase; Belongs to the GARS family.	0.824
guaB_3	purE	CLCHR_42470	CLCHR_09040	Inosine-5'-monophosphate dehydrogenase.	N5-carboxyaminoimidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).	0.811
guaB_3	purF	CLCHR_42470	CLCHR_09060	Inosine-5'-monophosphate dehydrogenase.	Amidophosphoribosyltransferase precursor; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.	0.906
guaB_3	purH_2	CLCHR_42470	CLCHR_09090	Inosine-5'-monophosphate dehydrogenase.	Bifunctional purine biosynthesis protein PurH.	0.987
guaB_3	purL	CLCHR_42470	CLCHR_09030	Inosine-5'-monophosphate dehydrogenase.	Phosphoribosylformylglycinamidine synthase.	0.941
guaB_3	purM	CLCHR_42470	CLCHR_09070	Inosine-5'-monophosphate dehydrogenase.	Phosphoribosylformylglycinamidine cyclo-ligase.	0.903
guaB_3	purN	CLCHR_42470	CLCHR_09080	Inosine-5'-monophosphate dehydrogenase.	Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.	0.855