| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| OPJ59606.1 | ribD | CLCHR_33810 | CLCHR_43840 | Hypothetical protein. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.861 |
| OPJ59606.1 | ribE | CLCHR_33810 | CLCHR_43830 | Hypothetical protein. | Riboflavin synthase. | 0.573 |
| OPJ59606.1 | ribH | CLCHR_33810 | CLCHR_43810 | Hypothetical protein. | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. | 0.562 |
| eno | ndkA | CLCHR_23170 | CLCHR_46630 | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.810 |
| eno | ribD | CLCHR_23170 | CLCHR_43840 | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.903 |
| folE | hisI | CLCHR_44090 | CLCHR_29350 | GTP cyclohydrolase 1. | Histidine biosynthesis bifunctional protein HisIE; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.693 |
| folE | ndkA | CLCHR_44090 | CLCHR_46630 | GTP cyclohydrolase 1. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.858 |
| folE | ribBA | CLCHR_44090 | CLCHR_43820 | GTP cyclohydrolase 1. | Riboflavin biosynthesis protein RibBA; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. | 0.908 |
| folE | ribD | CLCHR_44090 | CLCHR_43840 | GTP cyclohydrolase 1. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.925 |
| folE | ribE | CLCHR_44090 | CLCHR_43830 | GTP cyclohydrolase 1. | Riboflavin synthase. | 0.678 |
| folE | ribH | CLCHR_44090 | CLCHR_43810 | GTP cyclohydrolase 1. | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. | 0.674 |
| hisI | folE | CLCHR_29350 | CLCHR_44090 | Histidine biosynthesis bifunctional protein HisIE; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | GTP cyclohydrolase 1. | 0.693 |
| hisI | ndkA | CLCHR_29350 | CLCHR_46630 | Histidine biosynthesis bifunctional protein HisIE; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.464 |
| hisI | ribBA | CLCHR_29350 | CLCHR_43820 | Histidine biosynthesis bifunctional protein HisIE; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | Riboflavin biosynthesis protein RibBA; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. | 0.843 |
| hisI | ribD | CLCHR_29350 | CLCHR_43840 | Histidine biosynthesis bifunctional protein HisIE; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.899 |
| ndkA | eno | CLCHR_46630 | CLCHR_23170 | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. | 0.810 |
| ndkA | folE | CLCHR_46630 | CLCHR_44090 | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | GTP cyclohydrolase 1. | 0.858 |
| ndkA | hisI | CLCHR_46630 | CLCHR_29350 | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | Histidine biosynthesis bifunctional protein HisIE; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.464 |
| ndkA | ribBA | CLCHR_46630 | CLCHR_43820 | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | Riboflavin biosynthesis protein RibBA; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. | 0.945 |
| ndkA | ribD | CLCHR_46630 | CLCHR_43840 | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.862 |