node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EPUL_000219 | EPUL_000239 | A0A2S4Q0N9 | A0A2S4PZI0 | Uncharacterized protein; Belongs to the PI3/PI4-kinase family. | Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. | 0.976 |
EPUL_000219 | EPUL_001504 | A0A2S4Q0N9 | A0A2S4PXQ2 | Uncharacterized protein; Belongs to the PI3/PI4-kinase family. | Uncharacterized protein. | 0.901 |
EPUL_000219 | EPUL_001710 | A0A2S4Q0N9 | A0A2S4PXI8 | Uncharacterized protein; Belongs to the PI3/PI4-kinase family. | Uncharacterized protein. | 0.928 |
EPUL_000219 | EPUL_001850 | A0A2S4Q0N9 | A0A2S4PTS8 | Uncharacterized protein; Belongs to the PI3/PI4-kinase family. | RECA_2 domain-containing protein. | 0.800 |
EPUL_000219 | EPUL_002510 | A0A2S4Q0N9 | A0A2S4PR51 | Uncharacterized protein; Belongs to the PI3/PI4-kinase family. | Uncharacterized protein. | 0.969 |
EPUL_000219 | EPUL_002663 | A0A2S4Q0N9 | A0A2S4PQ75 | Uncharacterized protein; Belongs to the PI3/PI4-kinase family. | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. | 0.750 |
EPUL_000219 | EPUL_002913 | A0A2S4Q0N9 | A0A2S4PX55 | Uncharacterized protein; Belongs to the PI3/PI4-kinase family. | DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily. | 0.886 |
EPUL_000219 | EPUL_003314 | A0A2S4Q0N9 | A0A2S4PTS6 | Uncharacterized protein; Belongs to the PI3/PI4-kinase family. | Mre11_DNA_bind domain-containing protein; Belongs to the MRE11/RAD32 family. | 0.971 |
EPUL_000219 | EPUL_004071 | A0A2S4Q0N9 | A0A2S4PW90 | Uncharacterized protein; Belongs to the PI3/PI4-kinase family. | 3'-5' exonuclease domain-containing protein. | 0.999 |
EPUL_000219 | FEN1 | A0A2S4Q0N9 | A0A2S4Q0V1 | Uncharacterized protein; Belongs to the PI3/PI4-kinase family. | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | 0.813 |
EPUL_000239 | EPUL_000219 | A0A2S4PZI0 | A0A2S4Q0N9 | Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. | Uncharacterized protein; Belongs to the PI3/PI4-kinase family. | 0.976 |
EPUL_000239 | EPUL_001504 | A0A2S4PZI0 | A0A2S4PXQ2 | Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. | Uncharacterized protein. | 0.860 |
EPUL_000239 | EPUL_001710 | A0A2S4PZI0 | A0A2S4PXI8 | Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. | Uncharacterized protein. | 0.995 |
EPUL_000239 | EPUL_001850 | A0A2S4PZI0 | A0A2S4PTS8 | Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. | RECA_2 domain-containing protein. | 0.959 |
EPUL_000239 | EPUL_002510 | A0A2S4PZI0 | A0A2S4PR51 | Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. | Uncharacterized protein. | 0.998 |
EPUL_000239 | EPUL_002663 | A0A2S4PZI0 | A0A2S4PQ75 | Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. | 0.986 |
EPUL_000239 | EPUL_002913 | A0A2S4PZI0 | A0A2S4PX55 | Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. | DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily. | 0.985 |
EPUL_000239 | EPUL_003314 | A0A2S4PZI0 | A0A2S4PTS6 | Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. | Mre11_DNA_bind domain-containing protein; Belongs to the MRE11/RAD32 family. | 0.959 |
EPUL_000239 | EPUL_004071 | A0A2S4PZI0 | A0A2S4PW90 | Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. | 3'-5' exonuclease domain-containing protein. | 0.999 |
EPUL_000239 | FEN1 | A0A2S4PZI0 | A0A2S4Q0V1 | Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | 0.824 |