node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Sps_00643 | Sps_01181 | Sps_00643 | Sps_01181 | Dinucleotide-utilizing enzyme; PFAM: ThiS family; MoeZ/MoeB domain; Rhodanese-like domain; ThiF family. | Sulfur carrier protein ThiS; PFAM: ThiS family; TIGRFAM: thiamine biosynthesis protein ThiS. | 0.951 |
Sps_00643 | thiI | Sps_00643 | Sps_02241 | Dinucleotide-utilizing enzyme; PFAM: ThiS family; MoeZ/MoeB domain; Rhodanese-like domain; ThiF family. | (ThiS-adenylate) sulfurtransferase; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. | 0.715 |
Sps_00643 | ttcA | Sps_00643 | Sps_00915 | Dinucleotide-utilizing enzyme; PFAM: ThiS family; MoeZ/MoeB domain; Rhodanese-like domain; ThiF family. | Putative ATPase of the PP-loop superfamily implicated in cell cycle control; Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system. | 0.773 |
Sps_00916 | ttcA | Sps_00916 | Sps_00915 | PFAM: Universal stress protein family. | Putative ATPase of the PP-loop superfamily implicated in cell cycle control; Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system. | 0.591 |
Sps_01181 | Sps_00643 | Sps_01181 | Sps_00643 | Sulfur carrier protein ThiS; PFAM: ThiS family; TIGRFAM: thiamine biosynthesis protein ThiS. | Dinucleotide-utilizing enzyme; PFAM: ThiS family; MoeZ/MoeB domain; Rhodanese-like domain; ThiF family. | 0.951 |
Sps_01181 | ttcA | Sps_01181 | Sps_00915 | Sulfur carrier protein ThiS; PFAM: ThiS family; TIGRFAM: thiamine biosynthesis protein ThiS. | Putative ATPase of the PP-loop superfamily implicated in cell cycle control; Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system. | 0.779 |
Sps_03916 | miaA | Sps_03916 | Sps_05081 | Putative SAM-dependent methyltransferase; PFAM: Family of unknown function (DUF633). | tRNA isopentenyltransferase MiaA; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family. | 0.614 |
Sps_03916 | thiI | Sps_03916 | Sps_02241 | Putative SAM-dependent methyltransferase; PFAM: Family of unknown function (DUF633). | (ThiS-adenylate) sulfurtransferase; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. | 0.467 |
Sps_03916 | ttcA | Sps_03916 | Sps_00915 | Putative SAM-dependent methyltransferase; PFAM: Family of unknown function (DUF633). | Putative ATPase of the PP-loop superfamily implicated in cell cycle control; Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system. | 0.626 |
metG | miaA | Sps_01393 | Sps_05081 | methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | tRNA isopentenyltransferase MiaA; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family. | 0.531 |
metG | pth | Sps_01393 | Sps_04359 | methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | peptidyl-tRNA hydrolase; The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. Belongs to the PTH family. | 0.441 |
metG | thiI | Sps_01393 | Sps_02241 | methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | (ThiS-adenylate) sulfurtransferase; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. | 0.558 |
metG | ttcA | Sps_01393 | Sps_00915 | methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | Putative ATPase of the PP-loop superfamily implicated in cell cycle control; Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system. | 0.549 |
mfd | pth | Sps_01652 | Sps_04359 | Transcription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. | peptidyl-tRNA hydrolase; The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. Belongs to the PTH family. | 0.798 |
mfd | ttcA | Sps_01652 | Sps_00915 | Transcription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. | Putative ATPase of the PP-loop superfamily implicated in cell cycle control; Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system. | 0.626 |
miaA | Sps_03916 | Sps_05081 | Sps_03916 | tRNA isopentenyltransferase MiaA; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family. | Putative SAM-dependent methyltransferase; PFAM: Family of unknown function (DUF633). | 0.614 |
miaA | metG | Sps_05081 | Sps_01393 | tRNA isopentenyltransferase MiaA; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family. | methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | 0.531 |
miaA | pth | Sps_05081 | Sps_04359 | tRNA isopentenyltransferase MiaA; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family. | peptidyl-tRNA hydrolase; The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. Belongs to the PTH family. | 0.457 |
miaA | thiI | Sps_05081 | Sps_02241 | tRNA isopentenyltransferase MiaA; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family. | (ThiS-adenylate) sulfurtransferase; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. | 0.497 |
miaA | trmB | Sps_05081 | Sps_02351 | tRNA isopentenyltransferase MiaA; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family. | tRNA (guanine-N(7)-)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. | 0.432 |