node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Sps_03091 | Sps_05021 | Sps_03091 | Sps_05021 | Putative enzyme of heme biosynthesis; PFAM: HemX. | PFAM: Bacterial SH3 domain; TIGRFAM: SH3 domain protein. | 0.586 |
Sps_03091 | lapB | Sps_03091 | Sps_00820 | Putative enzyme of heme biosynthesis; PFAM: HemX. | Putative N-acetylglucosaminyl transferase; Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane; Belongs to the LapB family. | 0.593 |
Sps_03091 | slmA | Sps_03091 | Sps_03304 | Putative enzyme of heme biosynthesis; PFAM: HemX. | Transcriptional regulator, TetR family; Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions. | 0.500 |
Sps_03302 | dut | Sps_03302 | Sps_03303 | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.961 |
Sps_03302 | slmA | Sps_03302 | Sps_03304 | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Transcriptional regulator, TetR family; Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions. | 0.599 |
Sps_04113 | Sps_05021 | Sps_04113 | Sps_05021 | PFAM: Protein of unknown function (DUF416). | PFAM: Bacterial SH3 domain; TIGRFAM: SH3 domain protein. | 0.448 |
Sps_04113 | Sps_05105 | Sps_04113 | Sps_05105 | PFAM: Protein of unknown function (DUF416). | PFAM: Protein of unknown function (DUF1249). | 0.413 |
Sps_04113 | slmA | Sps_04113 | Sps_03304 | PFAM: Protein of unknown function (DUF416). | Transcriptional regulator, TetR family; Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions. | 0.439 |
Sps_05021 | Sps_03091 | Sps_05021 | Sps_03091 | PFAM: Bacterial SH3 domain; TIGRFAM: SH3 domain protein. | Putative enzyme of heme biosynthesis; PFAM: HemX. | 0.586 |
Sps_05021 | Sps_04113 | Sps_05021 | Sps_04113 | PFAM: Bacterial SH3 domain; TIGRFAM: SH3 domain protein. | PFAM: Protein of unknown function (DUF416). | 0.448 |
Sps_05021 | Sps_05105 | Sps_05021 | Sps_05105 | PFAM: Bacterial SH3 domain; TIGRFAM: SH3 domain protein. | PFAM: Protein of unknown function (DUF1249). | 0.481 |
Sps_05021 | slmA | Sps_05021 | Sps_03304 | PFAM: Bacterial SH3 domain; TIGRFAM: SH3 domain protein. | Transcriptional regulator, TetR family; Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions. | 0.439 |
Sps_05105 | Sps_04113 | Sps_05105 | Sps_04113 | PFAM: Protein of unknown function (DUF1249). | PFAM: Protein of unknown function (DUF416). | 0.413 |
Sps_05105 | Sps_05021 | Sps_05105 | Sps_05021 | PFAM: Protein of unknown function (DUF1249). | PFAM: Bacterial SH3 domain; TIGRFAM: SH3 domain protein. | 0.481 |
Sps_05105 | slmA | Sps_05105 | Sps_03304 | PFAM: Protein of unknown function (DUF1249). | Transcriptional regulator, TetR family; Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions. | 0.554 |
dut | Sps_03302 | Sps_03303 | Sps_03302 | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | 0.961 |
dut | slmA | Sps_03303 | Sps_03304 | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Transcriptional regulator, TetR family; Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions. | 0.884 |
ftsA | ftsZ | Sps_03269 | Sps_03268 | Cell division protein FtsA; Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring. Belongs to the FtsA/MreB family. | Cell division protein FtsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. | 0.997 |
ftsA | slmA | Sps_03269 | Sps_03304 | Cell division protein FtsA; Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring. Belongs to the FtsA/MreB family. | Transcriptional regulator, TetR family; Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions. | 0.457 |
ftsZ | ftsA | Sps_03268 | Sps_03269 | Cell division protein FtsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. | Cell division protein FtsA; Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring. Belongs to the FtsA/MreB family. | 0.997 |