node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Sps_00575 | Sps_02407 | Sps_00575 | Sps_02407 | Cystathionine beta-lyase; PFAM: Cys/Met metabolism PLP-dependent enzyme; 'TIGRFAM: cystathionine beta-lyase, bacterial'. | Aspartate kinase; 'PFAM: Homoserine dehydrogenase; Homoserine dehydrogenase, NAD binding domain; ACT domain; Amino acid kinase family'; TIGRFAM: aspartate kinase; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.948 |
Sps_00575 | Sps_02955 | Sps_00575 | Sps_02955 | Cystathionine beta-lyase; PFAM: Cys/Met metabolism PLP-dependent enzyme; 'TIGRFAM: cystathionine beta-lyase, bacterial'. | Aspartate kinase; 'PFAM: Homoserine dehydrogenase; Homoserine dehydrogenase, NAD binding domain; Amino acid kinase family'; TIGRFAM: aspartate kinase; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.948 |
Sps_00575 | Sps_02956 | Sps_00575 | Sps_02956 | Cystathionine beta-lyase; PFAM: Cys/Met metabolism PLP-dependent enzyme; 'TIGRFAM: cystathionine beta-lyase, bacterial'. | Cystathionine gamma-synthase; PFAM: Cys/Met metabolism PLP-dependent enzyme; TIGRFAM: O-succinylhomoserine (thiol)-lyase. | 0.935 |
Sps_00575 | Sps_04796 | Sps_00575 | Sps_04796 | Cystathionine beta-lyase; PFAM: Cys/Met metabolism PLP-dependent enzyme; 'TIGRFAM: cystathionine beta-lyase, bacterial'. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.978 |
Sps_00575 | Sps_04844 | Sps_00575 | Sps_04844 | Cystathionine beta-lyase; PFAM: Cys/Met metabolism PLP-dependent enzyme; 'TIGRFAM: cystathionine beta-lyase, bacterial'. | 5,10-methylenetetrahydrofolate reductase. | 0.694 |
Sps_00575 | metAS | Sps_00575 | Sps_02050 | Cystathionine beta-lyase; PFAM: Cys/Met metabolism PLP-dependent enzyme; 'TIGRFAM: cystathionine beta-lyase, bacterial'. | Homoserine O-succinyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine; Belongs to the MetA family. | 0.735 |
Sps_00575 | metE | Sps_00575 | Sps_04477 | Cystathionine beta-lyase; PFAM: Cys/Met metabolism PLP-dependent enzyme; 'TIGRFAM: cystathionine beta-lyase, bacterial'. | Methionine synthase (B12-independent); Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.967 |
Sps_01864 | Sps_02407 | Sps_01864 | Sps_02407 | Cystathionine beta-lyase/cystathionine gamma-synthase; PFAM: Cys/Met metabolism PLP-dependent enzyme; TIGRFAM: methionine gamma-lyase. | Aspartate kinase; 'PFAM: Homoserine dehydrogenase; Homoserine dehydrogenase, NAD binding domain; ACT domain; Amino acid kinase family'; TIGRFAM: aspartate kinase; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.751 |
Sps_01864 | Sps_02955 | Sps_01864 | Sps_02955 | Cystathionine beta-lyase/cystathionine gamma-synthase; PFAM: Cys/Met metabolism PLP-dependent enzyme; TIGRFAM: methionine gamma-lyase. | Aspartate kinase; 'PFAM: Homoserine dehydrogenase; Homoserine dehydrogenase, NAD binding domain; Amino acid kinase family'; TIGRFAM: aspartate kinase; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.751 |
Sps_01864 | Sps_02956 | Sps_01864 | Sps_02956 | Cystathionine beta-lyase/cystathionine gamma-synthase; PFAM: Cys/Met metabolism PLP-dependent enzyme; TIGRFAM: methionine gamma-lyase. | Cystathionine gamma-synthase; PFAM: Cys/Met metabolism PLP-dependent enzyme; TIGRFAM: O-succinylhomoserine (thiol)-lyase. | 0.831 |
Sps_01864 | Sps_04796 | Sps_01864 | Sps_04796 | Cystathionine beta-lyase/cystathionine gamma-synthase; PFAM: Cys/Met metabolism PLP-dependent enzyme; TIGRFAM: methionine gamma-lyase. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.978 |
Sps_01864 | Sps_04844 | Sps_01864 | Sps_04844 | Cystathionine beta-lyase/cystathionine gamma-synthase; PFAM: Cys/Met metabolism PLP-dependent enzyme; TIGRFAM: methionine gamma-lyase. | 5,10-methylenetetrahydrofolate reductase. | 0.694 |
Sps_01864 | metAS | Sps_01864 | Sps_02050 | Cystathionine beta-lyase/cystathionine gamma-synthase; PFAM: Cys/Met metabolism PLP-dependent enzyme; TIGRFAM: methionine gamma-lyase. | Homoserine O-succinyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine; Belongs to the MetA family. | 0.709 |
Sps_01864 | metE | Sps_01864 | Sps_04477 | Cystathionine beta-lyase/cystathionine gamma-synthase; PFAM: Cys/Met metabolism PLP-dependent enzyme; TIGRFAM: methionine gamma-lyase. | Methionine synthase (B12-independent); Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.967 |
Sps_01864 | metK | Sps_01864 | Sps_02642 | Cystathionine beta-lyase/cystathionine gamma-synthase; PFAM: Cys/Met metabolism PLP-dependent enzyme; TIGRFAM: methionine gamma-lyase. | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.927 |
Sps_02407 | Sps_00575 | Sps_02407 | Sps_00575 | Aspartate kinase; 'PFAM: Homoserine dehydrogenase; Homoserine dehydrogenase, NAD binding domain; ACT domain; Amino acid kinase family'; TIGRFAM: aspartate kinase; In the C-terminal section; belongs to the homoserine dehydrogenase family. | Cystathionine beta-lyase; PFAM: Cys/Met metabolism PLP-dependent enzyme; 'TIGRFAM: cystathionine beta-lyase, bacterial'. | 0.948 |
Sps_02407 | Sps_01864 | Sps_02407 | Sps_01864 | Aspartate kinase; 'PFAM: Homoserine dehydrogenase; Homoserine dehydrogenase, NAD binding domain; ACT domain; Amino acid kinase family'; TIGRFAM: aspartate kinase; In the C-terminal section; belongs to the homoserine dehydrogenase family. | Cystathionine beta-lyase/cystathionine gamma-synthase; PFAM: Cys/Met metabolism PLP-dependent enzyme; TIGRFAM: methionine gamma-lyase. | 0.751 |
Sps_02407 | Sps_02955 | Sps_02407 | Sps_02955 | Aspartate kinase; 'PFAM: Homoserine dehydrogenase; Homoserine dehydrogenase, NAD binding domain; ACT domain; Amino acid kinase family'; TIGRFAM: aspartate kinase; In the C-terminal section; belongs to the homoserine dehydrogenase family. | Aspartate kinase; 'PFAM: Homoserine dehydrogenase; Homoserine dehydrogenase, NAD binding domain; Amino acid kinase family'; TIGRFAM: aspartate kinase; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.994 |
Sps_02407 | Sps_02956 | Sps_02407 | Sps_02956 | Aspartate kinase; 'PFAM: Homoserine dehydrogenase; Homoserine dehydrogenase, NAD binding domain; ACT domain; Amino acid kinase family'; TIGRFAM: aspartate kinase; In the C-terminal section; belongs to the homoserine dehydrogenase family. | Cystathionine gamma-synthase; PFAM: Cys/Met metabolism PLP-dependent enzyme; TIGRFAM: O-succinylhomoserine (thiol)-lyase. | 0.948 |
Sps_02407 | Sps_04796 | Sps_02407 | Sps_04796 | Aspartate kinase; 'PFAM: Homoserine dehydrogenase; Homoserine dehydrogenase, NAD binding domain; ACT domain; Amino acid kinase family'; TIGRFAM: aspartate kinase; In the C-terminal section; belongs to the homoserine dehydrogenase family. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.980 |