STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AQZ99529.1Isocitrate lyase; Derived by automated computational analysis using gene prediction method: Protein Homology. (443 aa)    
Predicted Functional Partners:
glcB
Malate synthase G; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily.
 
 
 0.996
AQZ97752.1
Glycolate oxidase iron-sulfur subunit; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
 0.915
AQZ98078.1
FAD-binding oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
 0.915
AQZ98688.1
Bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aconitase/IPM isomerase family.
     
 0.915
AQZ97562.1
Glyoxylate/hydroxypyruvate reductase A; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
 
 0.911
AQZ98836.1
D-glycerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
     
 0.908
AQZ97754.1
Glycolate oxidase subunit GlcE; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
 0.903
aceK
Bifunctional isocitrate dehydrogenase kinase/phosphatase; Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation.
 
  
 0.860
AQZ99885.1
Ureidoglycolate hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
 0.806
ackA
Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family.
   
  
 0.798
Your Current Organism:
Comamonas kerstersii
NCBI taxonomy Id: 225992
Other names: Acidovorax sp. 121606, Acidovorax sp. 202149, C. kerstersii, CCUG 15333, Comamonas kerstersii Wauters et al. 2003, Commamonas terrigena DNA group 3, DSM 16026, LMG 3475, LMG:3475, strain AF61
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.